Eficacia y efectos renales tardíos de la cirugía conservadora de nefronas en el tratamiento del tumor de Wilms unilateral
Topic overview
Systematic review and meta-analysis comparing nephron-sparing surgery (NSS) versus radical nephrectomy for unilateral Wilms tumor in 10,979 patients. NSS demonstrated significantly improved long-term renal function (increased eGFR at follow-up) with comparable survival and recurrence rates to radical nephrectomy, supporting its safety and efficacy for renal preservation.
Key takeaways
- Nephron-sparing surgery (NSS) significantly improved eGFR at follow-up compared to diagnosis in unilateral Wilms tumor patients.
- NSS showed similar survival and recurrence rates compared to radical nephrectomy, with no significant oncologic outcome differences.
- NSS resulted in better long-term renal function preservation without compromising cancer control in unilateral Wilms tumor.
- Radical nephrectomy did not significantly decrease eGFR at follow-up, but NSS demonstrated superior renal function preservation.
- Current evidence supports NSS as safe and effective for unilateral Wilms tumor with comparable oncologic outcomes to radical nephrectomy.
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