Efficacy and late kidney effects of nephron-sparing surgery in the management of unilateral Wilms tumor
Topic overview
Systematic review and meta-analysis comparing nephron-sparing surgery (NSS) to radical nephrectomy (RN) in unilateral Wilms tumor shows NSS preserves renal function with similar survival and recurrence rates. Analysis of 10,979 patients demonstrates NSS significantly increases eGFR at follow-up while maintaining oncological safety.
Key takeaways
- Nephron-sparing surgery (NSS) significantly increases eGFR at follow-up compared to baseline in unilateral Wilms tumor patients.
- NSS shows equivalent survival and recurrence rates compared to radical nephrectomy, with no significant difference in oncologic outcomes.
- NSS preserves long-term renal function better than radical nephrectomy without compromising cancer control in selected unilateral WT cases.
- Meta-analysis of 10,979 patients demonstrates NSS is safe and effective for appropriately selected unilateral Wilms tumor patients.
- No significant difference in hypertension or renal dysfunction rates between NSS and radical nephrectomy at long-term follow-up.
Comments