Image-guided core-needle or surgical biopsy for neuroblastoma diagnosis in children
Topic overview
Systematic review comparing image-guided core-needle biopsy versus open surgical biopsy for neuroblastoma diagnosis in children. IGCNB achieved comparable diagnostic accuracy (90% vs 98%) with significantly fewer complications and lower transfusion rates than surgical biopsy, supporting its use as preferred diagnostic approach.
Key takeaways
- Image-guided core-needle biopsy achieves 90% tissue adequacy for neuroblastoma diagnosis, comparable to surgical biopsy (98%, p=.1)
- Surgical biopsy has 3.5x higher complication rate (21% vs 6%, p=.005) and higher transfusion needs (22% vs 6%, p=.0002)
- IGCNB provides sufficient tissue for biological characterization in 89% of cases, similar to surgical approach (95%, p=.15)
- IGCNB should be preferred over surgical biopsy for neuroblastoma workup when feasible, per IPSO systematic review
- Meta-analysis of 490 pediatric patients demonstrates IGCNB as safe, less invasive alternative to open surgical biopsy
Comments