La búsqueda agresiva de un estado libre de enfermedad (NED) en el hepatoblastoma mejora la supervivencia
Topic overview
Estudio retrospectivo demuestra que lograr estado libre de enfermedad (NED) mediante intervenciones quirúrgicas agresivas, incluyendo metastasectomías pulmonares repetidas, mejora significativamente la supervivencia en hepatoblastoma. Pacientes de alto riesgo que alcanzaron NED tuvieron supervivencia similar a pacientes sin alto riesgo.
Key takeaways
- Achieving no evidence of disease (NED) status is essential for survival in hepatoblastoma patients across all risk groups.
- Aggressive surgical pursuit of NED, including repeated pulmonary metastasectomies, significantly improves 10-year overall and event-free survival.
- High-risk patients achieving NED have similar 10-year survival to non-high-risk patients, supporting aggressive resection strategies.
- Repeated lung metastasectomies (median 2.5 procedures) can achieve long-term survival even in high-risk bilateral disease.
- NED status inversely correlates with 5-year mortality (OR 0.006), making complete surgical resection the primary therapeutic goal.
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