Aggressive Pursuit of No Evidence of Disease Status in Hepatoblastoma Improves Survival: An Observational Study
Topic overview
Retrospective study of 50 hepatoblastoma patients demonstrates that aggressive surgical pursuit of no evidence of disease status significantly improves survival outcomes. Repeated pulmonary metastasectomies and complex resections achieved comparable long-term survival in high-risk patients when NED was attained.
Key takeaways
- Achieving no evidence of disease (NED) status is essential for survival in hepatoblastoma, with 82% of patients rendered NED in this cohort.
- Aggressive surgical approach including repeated pulmonary metastasectomies significantly improves outcomes even in high-risk hepatoblastoma patients.
- High-risk patients achieved similar 10-year overall survival to standard-risk patients when NED status was attained (P=0.83).
- Patients who achieved NED had dramatically reduced 5-year mortality (OR 0.006) compared to those who did not achieve NED status.
- Repeated interventions are justified: high-risk patients underwent median 2.5 pulmonary metastasectomies with successful long-term salvage.
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