Non-Hodgkin Lymphoma PDQ®

In brief

NCI's evidence-based clinical reference for healthcare professionals managing childhood non-Hodgkin lymphoma. Provides comprehensive treatment protocols, risk stratification, and therapeutic approaches for pediatric lymphoid malignancies including B-cell and T-cell subtypes.

• Childhood non-Hodgkin lymphoma requires different treatment approaches than adult NHL due to distinct biology and histology.
• Aggressive chemotherapy regimens are standard, with treatment intensity based on stage and histologic subtype.
• CNS prophylaxis is critical in high-risk subtypes like lymphoblastic lymphoma and Burkitt lymphoma.
• Prognosis varies significantly by subtype: Burkitt and lymphoblastic lymphomas have cure rates exceeding 80% with modern therapy.
• Multidisciplinary care including pediatric oncology, surgery, and radiation oncology optimizes outcomes.

Written by the GCMD Library team from the guideline.