Neuroblastoma is the most common extracranial solid tumor in children, often presenting with abdominal mass or metastatic disease.

Risk stratification uses age, stage, MYCN amplification, and histology to guide treatment intensity from observation to multimodal therapy.

High-risk disease requires intensive chemotherapy, surgery, radiation, stem cell transplant, and immunotherapy for optimal outcomes.

Infants with localized disease may have spontaneous regression; observation alone is appropriate for select low-risk patients.

Long-term surveillance is essential due to risks of recurrence, secondary malignancies, and treatment-related late effects.

Neuroblastoma PDQ® | GlobalCastMD Clinical Guidelines

Guideline document

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Topic overview

Comprehensive NCI clinical reference for healthcare professionals managing neuroblastoma, the most common extracranial solid tumor in children. Covers evidence-based treatment protocols including risk-based stratification, multimodal therapy approaches with surgery, chemotherapy, radiation, and immunotherapy, plus prognostic factors and current clinical trial information.

Key Takeaways

Neuroblastoma is the most common extracranial solid tumor in children, often presenting with abdominal mass or metastatic disease.
Risk stratification uses age, stage, MYCN amplification, and histology to guide treatment intensity from observation to multimodal therapy.
High-risk disease requires intensive chemotherapy, surgery, radiation, stem cell transplant, and immunotherapy for optimal outcomes.
Infants with localized disease may have spontaneous regression; observation alone is appropriate for select low-risk patients.
Long-term surveillance is essential due to risks of recurrence, secondary malignancies, and treatment-related late effects.

Keywords

Hashtags

#Neuroblastoma #PediatricOncology #ChildhoodCancer #NCIGuidelines

Full guideline text

Full text not available for this guideline

How to cite: GlobalCastMD. Neuroblastoma PDQ®. GlobalCastMD Medical Library. https://library.globalcastmd.com/guideline/2381