Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms that can occur in pediatric populations with distinct biology from adult GISTs.

Pediatric GISTs often lack KIT/PDGFRA mutations common in adults, requiring different diagnostic and therapeutic approaches.

Treatment typically involves surgical resection with consideration of targeted therapy based on molecular profiling.

Multidisciplinary management is essential given the rarity and complexity of pediatric GIST cases.

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Clinical Guideline

Gastrointestinal Stromal Tumors PDQ®

2020-03-12

Topic overview

NCI's evidence-based clinical reference for healthcare professionals managing pediatric gastrointestinal stromal tumors (GIST). Covers diagnosis, molecular characteristics, and treatment approaches for these rare mesenchymal neoplasms in children, including targeted therapy options.

Key Takeaways

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms that can occur in pediatric populations with distinct biology from adult GISTs.
Pediatric GISTs often lack KIT/PDGFRA mutations common in adults, requiring different diagnostic and therapeutic approaches.
Treatment typically involves surgical resection with consideration of targeted therapy based on molecular profiling.
Multidisciplinary management is essential given the rarity and complexity of pediatric GIST cases.

Keywords

Hashtags

#GIST #PediatricOncology #RareTumors #TargetedTherapy

Full guideline text

Full text not available for this guideline

How to cite: GlobalCastMD. Gastrointestinal Stromal Tumors PDQ®. GlobalCastMD Medical Library. https://library.globalcastmd.com/guideline/2373

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