Guideline document
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Ewing Sarcoma PDQ®
Topic overview
NCI's evidence-based clinical reference for healthcare professionals managing Ewing sarcoma, a rare bone and soft tissue malignancy primarily affecting children and young adults. Covers diagnostic approaches, multimodal treatment strategies including chemotherapy, surgery, and radiation, and prognostic factors for this aggressive tumor.
Key Takeaways
- Ewing sarcoma is a rare bone and soft tissue malignancy requiring multimodal treatment with chemotherapy, surgery, and/or radiation.
- Most common in adolescents and young adults; presents with pain, swelling, and systemic symptoms like fever.
- Diagnosis requires biopsy with molecular confirmation of EWSR1 gene rearrangement (pathognomonic translocation).
- Treatment involves neoadjuvant chemotherapy followed by local control (surgery preferred over radiation when feasible).
- Prognosis depends on tumor size, location, metastatic status at diagnosis, and response to initial chemotherapy.
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Full guideline text
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How to cite: GlobalCastMD. Ewing Sarcoma PDQ®. GlobalCastMD Medical Library. https://library.globalcastmd.com/guideline/2366
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