Marietta Jank

22 statements · 1 topic · summaries given as host listed separately

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▶ Ep 32 · 0:40
Congenital diaphragmatic hernia, CDH is characterized by a diaphragmatic defect and abnormal lung development with varying degrees of pulmonary hypoplasia and hypertension.
quote · Congenital Diaphragmatic Hernia
▶ Ep 32 · 2:10
Cited 2, therefore, is critical for the development of heart, lung, and diaphragm, and therefore an interesting candidate in the pathogenesis of CDH.
quote · Congenital Diaphragmatic Hernia

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Marietta's statements about Congenital Diaphragmatic Hernia 22 statements

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Dr. Marietta Jank - Best of the Best in Pediatric Surgery 2025

▶ Ep 32 · 0:28
epidemiological Approximately 25% of CDH patients have concurrent cardiac anomalies. ↗
▶ Ep 32 · 0:40
quote Congenital diaphragmatic hernia, CDH is characterized by a diaphragmatic defect and abnormal lung development with varying degrees of pulmonary hypoplasia and hypertension. ↗
▶ Ep 32 · 1:10
clinical CITED2 is a transcriptional modulator that can be induced by hypoxia, interleukins, interferon gamma, TNF alpha and LPS. ↗
▶ Ep 32 · 1:10
quote Cited 2 is a transcriptional modulator and can be induced by hypoxia, interlukins, interferon gamma, TNF alpha and LPS. ↗
▶ Ep 32 · 1:30
clinical CITED2 binds with high affinity to coactivators regulating transactivation of multiple transcription factors including HIF-1 alpha, NF-kappa-B, PPAR gamma, and SMAD 2 and 3. ↗
▶ Ep 32 · 1:45
clinical CITED2 null mutant mice and rats are embryonic and perinatal lethal, or in the case of rats die within the first few hours after birth, exhibiting lung and cardiac anomalies. ↗
▶ Ep 32 · 2:00
clinical CITED2 is required for lung maturation and is detected in the septum transversum of the developing diaphragm. ↗
▶ Ep 32 · 2:10
quote Cited 2, therefore, is critical for the development of heart, lung, and diaphragm, and therefore an interesting candidate in the pathogenesis of CDH. ↗
▶ Ep 32 · 2:40
clinical At embryonic day 15 in the nitrofen rat model, there was no difference in CITED2 expression between CDH and control lungs. ↗
▶ Ep 32 · 2:55
clinical At embryonic day 18, there was a decreased expression of CITED2 in nitrofen-induced CDH lungs, which was significant in in situ hybridization staining. ↗
▶ Ep 32 · 3:10
clinical At embryonic stage 21, there was an increased expression of CITED2 in both in situ hybridization and on QPCR level in nitrofen-induced lungs. ↗
▶ Ep 32 · 3:25
clinical Increased CITED2 staining was confirmed on a protein level in the epithelial layer of nitrofen-induced lungs. ↗
▶ Ep 32 · 4:00
clinical Human fetal CDH lungs at late gestation showed a significantly increased abundance of CITED2 compared to controls, similar to the nitrofen model pattern. ↗
▶ Ep 32 · 4:15
clinical Genomic sequencing of isolated CDH patients found a hotspot at the chromosomal coordinates for CITED2 on chromosome 6 compared to controls. ↗
▶ Ep 32 · 4:40
opinion CITED2 may play a minor role in early lung development. ↗
▶ Ep 32 · 5:05
opinion At E18, CITED2 may promote pulmonary maturation. ↗
▶ Ep 32 · 5:25
quote So we hypothesize that cited 2 orchestrates the inflammatory response in nitrofen induced abnormal lung development. ↗
▶ Ep 32 · 5:25
opinion CITED2 orchestrates the inflammatory response in nitrofen-induced abnormal lung development at late gestation. ↗
▶ Ep 32 · 5:40
clinical Proteomic data showed altered inflammatory pathways at E21 nitrofen lungs with increased abundance of CBP, NF-kappa-B and STAT3, which are all interacting factors of CITED2. ↗
▶ Ep 32 · 5:55
opinion CITED2 may be induced by NF-kappa-B signaling and acts as a negative feedback regulation of NF-kappa-B in the nucleus. ↗
▶ Ep 32 · 5:55
quote So we put forward that cited 2 may be induced by NF Kappa B signaling and acts as a negative feedback regulation of NF Kappa B in the nucleus. ↗
▶ Ep 32 · 7:10
clinical The research team is collaborating with Kansas University for a CRISPR-Cas9 CITED2 mutant rat to investigate lung morphology throughout development. ↗

Summaries Marietta gave as host · 5 summaries

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Summaries Marietta gave as host · Congenital Diaphragmatic Hernia 5 summaries

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Dr. Marietta Jank - Best of the Best in Pediatric Surgery 2025

▶ Ep 32 · 4:45
host summary Marietta Jank summarizing the discussion: CITED2 expression is low at early lung development according to literature. ↗
▶ Ep 32 · 4:55
host summary Marietta Jank summarizing the discussion: CITED2 deficient mice showed no difference in lung phenotype compared to controls at embryonic day 16.5. ↗
▶ Ep 32 · 5:05
host summary Marietta Jank summarizing the discussion: CITED2 null mutant mice embryos at E17.5 and 18.5 showed signs of pulmonary immaturity with smaller lobe size, increased percentage of tissue and loss of air space. ↗
▶ Ep 32 · 5:20
host summary Marietta Jank summarizing the discussion: CITED2 mutant rats showed arrest at canalicular stage. ↗
▶ Ep 32 · 5:25
host summary Marietta Jank summarizing the discussion: CITED2 itself is induced by proinflammatory stimuli like LPS, interleukins, interferon gamma and TNF alpha according to current literature. ↗