In conclusion, CD56 IHC stain is helpful as a complementary test in liver biopsies to rule out biliary atresia as an etiology for neonates presenting with cholestasis.
BOB Ped Surg 2023 - Maria Soledad Jara Valdivia, CIPESUR - Presentation
▶Ep 15 · 0:00
clinicalBiliary atresia leads to liver cirrhosis without early treatment↗
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quoteThe immunohistochemical staining CD56 is useful in the diagnosis of biliary atresia.↗
▶Ep 15 · 0:20
clinicalThe diagnosis of BA can be challenging as its histopathologic features overlap with those of other pediatric cholestatic liver diseases↗
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clinicalThe most helpful hallmark of BA on histology is portal fibrosis and bile duct proliferation↗
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clinicalA similar pattern to BA can be found in other causes of cholestasis such as familiar intrahepatic cholestasis, neonatal hepatitis, and Alagille syndrome↗
▶Ep 15 · 1:10
clinicalDuring cirrhosis, biliary epithelial structure express immunohistochemical markers of immaturity such as CD56↗
▶Ep 15 · 2:40
quoteCD56+ was defined as presence greater than 5% in the ductular epithelial cells.↗
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epidemiological639 biopsies were performed between 2013 and 2019↗
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epidemiologicalFinal groups were distributed as: group BA equals 30 patients, group NC equals 28 patients, group C no BA equals 31↗
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clinicalCD56 plus had sensitivity of 74% for BA versus 16% and 9% for other groups↗
▶Ep 15 · 3:35
clinicalCD56 plus had specificity of 87.7% for BA versus 61% and 50% for other groups↗
▶Ep 15 · 3:45
clinicalThe PPV was 76% for BA versus 18% and 9% for other groups↗
▶Ep 15 · 3:55
clinicalThe NPV was 80% for BA versus 57% and 50% for other groups↗
clinicalThe labeling quantile from 6 to 25% had a higher sensitivity and adequate specificity↗
▶Ep 15 · 4:30
clinicalCD56 in more than 5% of the ductular epithelial cells has a sensitivity of 74.2% versus 16.1% and 9.68% in non-BA groups↗
▶Ep 15 · 4:45
clinicalCD56 has specificity of 87.7% and LHR+ of 6.04 compared to 0.42 and 0.20 in non BA group to diagnose biliary atresia↗
▶Ep 15 · 4:55
clinicalAn NPV of 86.2% shows that if CD56 is negative, biliary atresia is unlikely↗
▶Ep 15 · 5:05
opinionCD56 IHC stain is helpful as a complementary test in liver biopsies to rule out biliary atresia as an etiology for neonates presenting with cholestasis↗
▶Ep 15 · 5:05
quoteIn conclusion, CD56 IHC stain is helpful as a complementary test in liver biopsies to rule out biliary atresia as an etiology for neonates presenting with cholestasis.↗
