Kasir Collaj

15 timestamped statements across 1 collection — auto-found in recorded discussions, each timestamp jumps to the exact moment.

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▶ Ep 11 · 3:55
Remarkably, when we treat these hypoplastic lungs with the amniotic fluid stem cell derived extracellular vesicles, we are able to restore these primary markers, as you can see in the green shaded area, thus indicating that cell homeostasis can be achieved.
quote · Congenital Diaphragmatic Hernia
▶ Ep 11 · 1:35
One of the biggest challenges for babies with CDH is that fetal hypoplastic lungs are immature, whereby there is an impairment of cell differentiation, especially in the epithelium.
quote · Congenital Diaphragmatic Hernia

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Congenital Diaphragmatic Hernia 15 entries

Best of the Best in Pediatric Surgery Winner Announcement

▶ Ep 11 · 1:13
clinical Congenital diaphragmatic hernia is characterized by impaired fetal lung growth and maturation with unacceptably high mortality and morbidity rates. ↗
▶ Ep 11 · 1:13
quote Congenital diaphragmatic hernia is characterized by impaired fetal lung growth and maturation. This condition has unacceptably high mortality and morbidity rates. ↗
▶ Ep 11 · 1:35
quote One of the biggest challenges for babies with CDH is that fetal hypoplastic lungs are immature, whereby there is an impairment of cell differentiation, especially in the epithelium. ↗
▶ Ep 11 · 1:35
clinical One of the biggest challenges for babies with CDH is that fetal hypoplastic lungs are immature with impairment of cell differentiation, especially in the epithelium. ↗
▶ Ep 11 · 1:50
clinical Extracellular vesicles (EVs) are the main mediators of stem cell paracrine signaling. ↗
▶ Ep 11 · 2:05
clinical Amniotic fluid stem cell derived EVs can rescue fetal lung growth and maturation in several models of CDH at the pseudoglandular stage, which corresponds to 7 to 16 weeks of human gestation. ↗
▶ Ep 11 · 2:35
clinical CDH is diagnosed around 18 to 20 weeks gestation. ↗
▶ Ep 11 · 2:50
clinical The nitrophin model is a well-established model for studying CDH, created by administering the herbicide nitrophin to pregnant rat dams at embryonic day 9.5. ↗
▶ Ep 11 · 3:30
clinical Hypoplastic lungs at canalicular and saccular stages show down-regulation of alveolar type 1 and 2 cells, as well as basal and club cells compared to control. ↗
▶ Ep 11 · 3:55
quote Remarkably, when we treat these hypoplastic lungs with the amniotic fluid stem cell derived extracellular vesicles, we are able to restore these primary markers, as you can see in the green shaded area, thus indicating that cell homeostasis can be achieved. ↗
▶ Ep 11 · 3:55
clinical Treatment of hypoplastic lungs with amniotic fluid stem cell derived extracellular vesicles restores primary markers of alveolar type 1 and 2 cells, basal cells, and club cells, indicating that cell homeostasis can be achieved. ↗
▶ Ep 11 · 5:26
clinical In vivo experiments have been performed in a rat model using different administration routes including intraamniotic and tracheal, with promising results. ↗
▶ Ep 11 · 6:20
clinical There is active collaboration with Dr. Jan De Prest to investigate the safety and feasibility of EV treatment in a lab model. ↗
▶ Ep 11 · 7:17
clinical Ciliated cells did not show a difference with EV treatment, potentially due to an imbalance of different cell types in the hypoplastic fetal lung creating a different homeostatic cell composition. ↗
▶ Ep 11 · 7:40
clinical Key markers expressed in branching morphogenesis are being rescued effectively by EV treatment, suggesting the importance is the greater cell homeostatic balance rather than any specific cell type. ↗