until you really understand the true phenotype of the patient and their genotype, you're not going to be able to identify which patients are going to be able to be enrolled into a trial
patients can certainly have acute recurrent pancreatitis and not have the evidence of ductile changes or pancreatic atrophy or pancreatic function loss
Evaluation for TPIAT requires multidisciplinary assessment including gastroenterology, surgery, endocrine, pain team, human genetics, infectious disease, social workers and other ancillary services
Total Pancreatectomy with Islet Autotransplantation: Pancreatic Disease
▶Ep 2 · 1:33
quoteselecting the right patient is probably as critical as doing the surgery itself↗
▶Ep 2 · 4:44
guidelineTPIAT is indicated for chronic pain unresponsive to medical and endoscopic approaches or surgical approaches and significantly impaired quality of life with repeated acute pancreatitis episodes↗
▶Ep 2 · 5:28
guidelineThe main indication for TPIAT is chronic pain unresponsive to optimal medical and endoscopic approaches and significantly impaired quality of life↗
▶Ep 2 · 6:02
guidelineEvaluation for TPIAT requires multidisciplinary assessment including gastroenterology, surgery, endocrine, pain team, human genetics, infectious disease, social workers and other ancillary services↗
▶Ep 2 · 7:27
clinicalSocial workers assess support structures, resources, and assist with school and work issues, with families away from home for at least 6 to 8 weeks for TPIAT↗
▶Ep 2 · 7:52
guidelineInfectious disease team ensures immunizations are up to date, discusses post-splenectomy prophylaxis and management, and evaluates for MRSA colonization prior to surgery↗
Total Pancreatectomy with Islet Autotransplantation: Pancreatic Disease
▶Ep 9 · 1:33
quoteselecting the right patient is probably as critical as doing the surgery itself↗
▶Ep 9 · 4:44
guidelineTPIAT is indicated for chronic pain unresponsive to medical and endoscopic approaches or surgical approaches and significantly impaired quality of life with repeated acute pancreatitis episodes↗
▶Ep 9 · 5:28
guidelineThe main indication for TPIAT is chronic pain unresponsive to optimal medical and endoscopic approaches and significantly impaired quality of life↗
▶Ep 9 · 6:02
guidelineEvaluation for TPIAT requires multidisciplinary assessment including gastroenterology, surgery, endocrine, pain team, human genetics, infectious disease, social workers and other ancillary services↗
▶Ep 9 · 7:27
clinicalSocial workers assess support structures, resources, and assist with school and work issues, with families away from home for at least 6 to 8 weeks for TPIAT↗
▶Ep 9 · 7:52
guidelineInfectious disease team ensures immunizations are up to date, discusses post-splenectomy prophylaxis and management, and evaluates for MRSA colonization prior to surgery↗
Chronic Pancreatitis, Function Tests, & Pain Management: Pancreatic Disease
▶Ep 4 · 1:43
quoterecurrent pancreatitis and chronic pancreatitis are essentially the same thing↗
▶Ep 4 · 2:54
epidemiologicalBetween 7 and 34% of pediatric patients with acute pancreatitis will eventually develop recurrent episodes of pancreatitis↗
▶Ep 4 · 3:12
guidelineAcute recurrent pancreatitis is defined as two distinct episodes of acute pancreatitis with either complete resolution between episodes or complete normalization of enzymes between episodes↗
▶Ep 4 · 3:37
guidelineChronic pancreatitis requires a combination of clinical presentation and abnormal imaging findings including ductal irregularities, calcifications, or pancreatic gland atrophy↗
▶Ep 4 · 5:48
quotepatients can certainly have acute recurrent pancreatitis and not have the evidence of ductile changes or pancreatic atrophy or pancreatic function loss↗
▶Ep 4 · 5:48
clinicalPatients can have acute recurrent pancreatitis without evidence of ductal changes, pancreatic atrophy, or pancreatic function loss↗
▶Ep 4 · 5:59
quoteWhat leads them, tips them over the edge, what takes them from having acute recurrent pancreatitis to actually then developing chronic pancreatitis↗
▶Ep 4 · 9:46
quotein a 10-year-old who was previously healthy, this is, this is a very atypical finding↗
▶Ep 4 · 11:37
epidemiologicalIn pediatric populations, the main risk factors for chronic pancreatitis are genetic, followed by obstructive or anatomic processes↗
▶Ep 4 · 11:37
epidemiologicalIn adults, alcohol causes up to 70% of chronic pancreatitis cases↗
▶Ep 4 · 20:56
clinicalThe CF Foundation has an extensive pipeline of small molecules to optimize CFTR function, particularly for atypical mutations↗
▶Ep 4 · 21:37
quoteuntil you really understand the true phenotype of the patient and their genotype, you're not going to be able to identify which patients are going to be able to be enrolled into a trial↗
▶Ep 4 · 36:40
quotelow fat diet, PETs, antioxidants, and steroids have never been shown to prevent those episodes↗
▶Ep 4 · 36:40
clinicalLow fat diet, pancreatic enzyme replacement therapy, antioxidants, and steroids have never been shown to prevent recurrent pancreatitis episodes or pancreatic pain episodes↗
