Updated Favorable histology Wilms tumor risk stratification: Rationale for future Children’s Oncology Group clinical trials
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clinicalRisk stratification for Wilms tumor has evolved many times over the years.↗
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quoteRisk stratification for Wilm's tumor has evolved many times over the years, so let's catch up.↗
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guidelineThe Children's Oncology Group published updated risk stratification for patients with favorable histology Wilms tumor in Nature in June 2025.↗
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guidelineThe new risk stratification model includes biological and clinical features that were not in the first generation risk stratification.↗
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guidelineThe new model changes some of the older features or gets rid of them altogether.↗
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quoteFactors that are being added are loss of heterozygosity of 11P15C, 1Q gain. And lymph node involvement.↗
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guidelineFactors being added are loss of heterozygosity of 11P15, 1Q gain, and lymph node involvement.↗
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quoteTumor nephrectomy weight is no longer included.↗
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guidelineTumor nephrectomy weight is no longer included in the risk stratification.↗
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guidelineThe model modified how histology and age are used to stratify certain patients.↗
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opinionMore changes are expected in the future as ongoing COG trials produce more results.↗