Dominique Simmons

68 timestamped statements across 1 collection — auto-found in recorded discussions, each timestamp jumps to the exact moment.

Neuroblastoma · guest expert

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▶ Ep 15 · 5:48
Well, I've created it myself. So we do this with, um, basic image registration. There are some software tools available for this, but we use the main tool, uh, Elastics it's called, and you do this in program, uh, programming software such as Python or, um, MATLAB, uh, something like that, but there are multiple options.
quote · Neuroblastoma
▶ Ep 15 · 5:48
Well, I've created it myself. So we do this with, um, basic image registration. There are some software tools available for this, but we use the main tool, uh, Elastics it's called, and you do this in program, uh, programming software such as Python or, um, MATLAB, uh, something like that, but there are multiple options.
quote · Neuroblastoma

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Neuroblastoma 68 entries

Dominique Simons, MSc - Best of the Best in Pediatric Surgery 2024

▶ Ep 15 · 0:35
quote Neuroblastoma is a surgically challenging tumor to resect, and this is mainly due to the adhesion and encasement to important structures, the heterogeneity, and the therapy-induced changes. ↗
▶ Ep 15 · 0:35
clinical Neuroblastoma is surgically challenging to resect mainly due to adhesion and encasement to important structures, heterogeneity, and therapy-induced changes. ↗
▶ Ep 15 · 0:35
quote Neuroblastoma is a surgically challenging tumor to resect, and this is mainly due to the adhesion and encasement to important structures, the heterogeneity, and the therapy-induced changes. ↗
▶ Ep 15 · 0:35
clinical Neuroblastoma is surgically challenging to resect mainly due to adhesion and encasement to important structures, heterogeneity, and therapy-induced changes. ↗
▶ Ep 15 · 0:45
guideline The surgical goal for neuroblastoma is to resect more than 95% of the tumor tissue while sparing anatomical structures. ↗
▶ Ep 15 · 0:45
guideline The surgical goal for neuroblastoma is to resect more than 95% of the tumor tissue while sparing anatomical structures. ↗
▶ Ep 15 · 0:45
quote So the goal for surgeons is to resect more than 95% of the tumor tissue while sparing those anatomical structures. ↗
▶ Ep 15 · 0:45
quote So the goal for surgeons is to resect more than 95% of the tumor tissue while sparing those anatomical structures. ↗
▶ Ep 15 · 0:53
clinical 3D models of patient-specific anatomy are routinely made to prepare surgeons for neuroblastoma resection. ↗
▶ Ep 15 · 0:53
clinical 3D models of patient-specific anatomy are routinely made to prepare surgeons for neuroblastoma resection. ↗
▶ Ep 15 · 0:57
clinical Complete resection of neuroblastoma is often very difficult or even impossible due to tumor location. ↗
▶ Ep 15 · 0:57
clinical Complete resection of neuroblastoma is often very difficult or even impossible due to tumor location. ↗
▶ Ep 15 · 1:07
clinical Surgeons face a dilemma of whether to resect more tumor tissue with possible complications such as bleeding or to leave residual tumor tissue. ↗
▶ Ep 15 · 1:07
clinical Surgeons face a dilemma of whether to resect more tumor tissue with possible complications such as bleeding or to leave residual tumor tissue. ↗
▶ Ep 15 · 1:17
quote And this led to the question, can we actually distinguish vital from non-vital tumor tissue since the nerveoblastoma is so heterogeneous? ↗
▶ Ep 15 · 1:17
quote And this led to the question, can we actually distinguish vital from non-vital tumor tissue since the nerveoblastoma is so heterogeneous? ↗
▶ Ep 15 · 1:26
opinion Biology can be used as a biomarker for tumor vitality in neuroblastoma. ↗
▶ Ep 15 · 1:26
opinion Biology can be used as a biomarker for tumor vitality in neuroblastoma. ↗
▶ Ep 15 · 1:36
clinical In MIBG SPECT-CT imaging, high uptake is associated with viable tumor tissue. ↗
▶ Ep 15 · 1:36
clinical In ADC imaging, diffusion restriction is associated with viable tumor tissue and appears as a low signal. ↗
▶ Ep 15 · 1:36
clinical In MIBG SPECT-CT imaging, high uptake is associated with viable tumor tissue. ↗
▶ Ep 15 · 1:36
clinical In ADC imaging, diffusion restriction is associated with viable tumor tissue and appears as a low signal. ↗
▶ Ep 15 · 1:52
clinical MIBG uptake and diffusion restriction in neuroblastoma change over time, suggesting the biology and vitality of the tumor may also change. ↗
▶ Ep 15 · 1:52
clinical MIBG uptake and diffusion restriction in neuroblastoma change over time, suggesting the biology and vitality of the tumor may also change. ↗
▶ Ep 15 · 2:10
clinical ADC and MIBG scans have different 3D positions from T1-weighted MRI, requiring image registration. ↗
▶ Ep 15 · 2:10
clinical ADC and MIBG scans have different 3D positions from T1-weighted MRI, requiring image registration. ↗
▶ Ep 15 · 2:18
clinical Registration accuracy is evaluated using the Dice coefficient (which measures overlap between two structures) and target registration error (which measures distance between two points). ↗
▶ Ep 15 · 2:18
clinical Registration accuracy is evaluated using the Dice coefficient (which measures overlap between two structures) and target registration error (which measures distance between two points). ↗
▶ Ep 15 · 2:30
clinical Risk group delineation uses ADC and MIBG values within the tumor volume with thresholds based on literature. ↗
▶ Ep 15 · 2:30
clinical Risk group delineation uses ADC and MIBG values within the tumor volume with thresholds based on literature. ↗
▶ Ep 15 · 2:41
clinical High-risk areas in the 3D model are associated with diffusion restriction and MIBG uptake. ↗
▶ Ep 15 · 2:41
clinical High-risk areas in the 3D model are associated with diffusion restriction and MIBG uptake. ↗
▶ Ep 15 · 2:58
epidemiological Seven patients with abdominal neuroblastoma eligible for surgery were included prospectively. ↗
▶ Ep 15 · 2:58
epidemiological Seven patients with abdominal neuroblastoma eligible for surgery were included prospectively. ↗
▶ Ep 15 · 3:10
clinical Accurate initial registration was achieved for all patients with a median Dice of 0.81 for ADC and 0.77 for MIBG. ↗
▶ Ep 15 · 3:10
clinical Multimodal 3D models were successfully created for every patient in the study. ↗
▶ Ep 15 · 3:10
quote We achieved an accurate initial registration for all patients with a median dies of 0.81 for the ADC and the median dies of 0.77 for the MIBG and the median target registration error was 5.3 for the ADC and 4.3 for MIBG and this allowed the creation of multi-modal 3D models for every patient. ↗
▶ Ep 15 · 3:10
clinical Accurate initial registration was achieved for all patients with a median Dice of 0.81 for ADC and 0.77 for MIBG. ↗
▶ Ep 15 · 3:10
clinical Median target registration error was 5.3 mm for ADC and 4.3 mm for MIBG. ↗
▶ Ep 15 · 3:10
clinical Multimodal 3D models were successfully created for every patient in the study. ↗
▶ Ep 15 · 3:10
quote We achieved an accurate initial registration for all patients with a median dies of 0.81 for the ADC and the median dies of 0.77 for the MIBG and the median target registration error was 5.3 for the ADC and 4.3 for MIBG and this allowed the creation of multi-modal 3D models for every patient. ↗
▶ Ep 15 · 3:10
clinical Median target registration error was 5.3 mm for ADC and 4.3 mm for MIBG. ↗
▶ Ep 15 · 3:37
clinical In some cases, ADC and MIBG risk models showed similar patterns, with the lateral side of the tumor marked as high risk and the medial side as low risk. ↗
▶ Ep 15 · 3:37
clinical In some cases, ADC and MIBG risk models showed similar patterns, with the lateral side of the tumor marked as high risk and the medial side as low risk. ↗
▶ Ep 15 · 3:52
clinical In other cases, ADC and MIBG identified completely different regions as high risk (e.g., cranial part high-risk on ADC versus a different region on MIBG). ↗
▶ Ep 15 · 3:52
clinical In other cases, ADC and MIBG identified completely different regions as high risk (e.g., cranial part high-risk on ADC versus a different region on MIBG). ↗
▶ Ep 15 · 4:09
quote And this led to the question of whether these areas really predict what the literature suggests and this brings me to, uh, my future perspectives. ↗
▶ Ep 15 · 4:09
quote And this led to the question of whether these areas really predict what the literature suggests and this brings me to, uh, my future perspectives. ↗
▶ Ep 15 · 4:53
quote Uh, however, there are still some limitations as the thresholds are based on limited literature which questions the reliability of our ABC and MIBG values that we use and we should evaluate the accuracy of the models. ↗
▶ Ep 15 · 4:53
opinion The thresholds used for risk stratification are based on limited literature, which questions the reliability of the ADC and MIBG values used. ↗
▶ Ep 15 · 4:53
opinion The thresholds used for risk stratification are based on limited literature, which questions the reliability of the ADC and MIBG values used. ↗
▶ Ep 15 · 4:53
quote Uh, however, there are still some limitations as the thresholds are based on limited literature which questions the reliability of our ABC and MIBG values that we use and we should evaluate the accuracy of the models. ↗
▶ Ep 15 · 5:48
clinical The image registration is performed using Elastix software in programming environments such as Python or MATLAB. ↗
▶ Ep 15 · 5:48
clinical The image registration is performed using Elastix software in programming environments such as Python or MATLAB. ↗
▶ Ep 15 · 5:48
quote Well, I've created it myself. So we do this with, um, basic image registration. There are some software tools available for this, but we use the main tool, uh, Elastics it's called, and you do this in program, uh, programming software such as Python or, um, MATLAB, uh, something like that, but there are multiple options. ↗
▶ Ep 15 · 5:48
quote Well, I've created it myself. So we do this with, um, basic image registration. There are some software tools available for this, but we use the main tool, uh, Elastics it's called, and you do this in program, uh, programming software such as Python or, um, MATLAB, uh, something like that, but there are multiple options. ↗
▶ Ep 15 · 6:14
quote Well, the main stubborn thing to do is to make the segmentation of the neuroblastoma. That's most of the time, uh, but actually the registration is about a few minutes. It's really quick. ↗
▶ Ep 15 · 6:14
clinical Segmentation of the neuroblastoma is the most time-consuming step; the actual registration takes only a few minutes. ↗
▶ Ep 15 · 6:14
clinical Segmentation of the neuroblastoma is the most time-consuming step; the actual registration takes only a few minutes. ↗
▶ Ep 15 · 6:14
quote Well, the main stubborn thing to do is to make the segmentation of the neuroblastoma. That's most of the time, uh, but actually the registration is about a few minutes. It's really quick. ↗
▶ Ep 15 · 7:07
clinical Simmons performs the 3D model creation herself with verification from radiologists, especially in early phases. ↗
▶ Ep 15 · 7:07
clinical Simmons performs the 3D model creation herself with verification from radiologists, especially in early phases. ↗
▶ Ep 15 · 7:07
quote I mainly do it myself with the help of, of course, radiologists because I always check them with them. Um, you get better over time, of course, but especially in the first phases, I always check my models with the radiologist uh to make sure that I was correct. ↗
▶ Ep 15 · 7:07
quote I mainly do it myself with the help of, of course, radiologists because I always check them with them. Um, you get better over time, of course, but especially in the first phases, I always check my models with the radiologist uh to make sure that I was correct. ↗
▶ Ep 15 · 7:22
quote And it's really interesting what you say about how this can possibly change because now we really believe that we should, uh, resect the MRBG positive area, but this shows that we may, maybe don't know. ↗
▶ Ep 15 · 7:22
opinion Current practice believes that MIBG-positive areas should be resected, but discordant ADC/MIBG findings suggest this may need re-evaluation. ↗
▶ Ep 15 · 7:22
quote And it's really interesting what you say about how this can possibly change because now we really believe that we should, uh, resect the MRBG positive area, but this shows that we may, maybe don't know. ↗
▶ Ep 15 · 7:22
opinion Current practice believes that MIBG-positive areas should be resected, but discordant ADC/MIBG findings suggest this may need re-evaluation. ↗