I really felt that vascular anomalies is an umbrella term, and even if you take lymphatic anomalies, there are many different kinds of lymphatic anomalies that maybe need different medicines.
guidelineThe ISSVA classification system was updated in 2014 and is based on John Mulligan's original classification from Boston Children's Hospital↗
▶Ep 8 · 2:58
clinicalLymphatic anomalies are classified into lymphatic tumors and lymphatic malformations, with malformations further divided into macrocystic, microcystic, combined lesions, generalized lymphatic anomaly, Gorham-Stout disease, and central conducting anomalies↗
▶Ep 8 · 15:17
quoteI really felt that vascular anomalies is an umbrella term, and even if you take lymphatic anomalies, there are many different kinds of lymphatic anomalies that maybe need different medicines.↗
▶Ep 8 · 15:43
clinicalSirolimus (rapamycin) is an mTOR inhibitor that blocks the PIK3CA pathway, which has been shown to be a somatic mutation in many lymphatic malformations↗
▶Ep 8 · 16:18
clinicalBoston Children's Hospital received FDA funding in 2008 to study sirolimus for complicated vascular anomalies based on the hypothesis that the PIK3CA pathway controls blood vessel growth↗
▶Ep 8 · 16:59
clinicalSirolimus improved quality of life, decreased pain, and reduced infection frequency in patients with complicated lymphatic anomalies↗
▶Ep 8 · 17:19
quoteI feel very passionate that it needs to be used in a controlled manner where we actually are following outcomes.↗
▶Ep 8 · 17:41
clinicalPreoperative sirolimus therapy can soften lymphatic tissue and decrease lesion size, making surgical procedures less extensive↗
▶Ep 8 · 38:09
clinicalWhen bleomycin was first used for vascular anomalies, there were reported cases of pneumonitis because practitioners didn't understand there is a maximum safe dose↗
