Tokyo approach to late presenters: decision based on timing of acholic stool onset, not chronological age—if acholic from birth, consider primary transplant; if yellow stool for first month of life, proceed to Kasai even at 100 days
Tokyo protocol: start prednisone 4mg/kg/day after CRP normalizes post-op, taper over 15 days (4→3→2→1→0.5mg/kg, 3 days each), return to higher dose if stool becomes acholic
quoteWhen we show the stool card, you know, they can understand what we are saying. So when we're talking to the parents, stool card, I feel very, very effective.↗
▶Ep 13 · 4:07
quoteWhen we show the stool card, you know, they can understand what we are saying. So when we're talking to the parents, stool card, I feel very, very effective.↗
▶Ep 13 · 7:32
clinicalInfants who initially had yellow stool that became clay-colored have better prognosis than those with clay-colored stool immediately after passing meconium.↗
▶Ep 13 · 7:32
clinicalInfants who initially had yellow stool that became clay-colored have better prognosis than those with clay-colored stool immediately after passing meconium.↗
▶Ep 13 · 21:41
clinicalLiver exteriorization with a small incision can cause kinking of hepatic veins.↗
▶Ep 13 · 21:41
clinicalLiver exteriorization with a small incision can cause kinking of hepatic veins.↗
▶Ep 13 · 23:17
clinicalRecent data from Juntendo shows liver function might be worse in the midterm follow-up for patients who had laparoscopic Kasai compared to open surgery.↗
▶Ep 13 · 23:17
clinicalRecent data from Juntendo shows liver function might be worse in the midterm follow-up for patients who had laparoscopic Kasai compared to open surgery.↗
▶Ep 13 · 30:34
clinicalYamataka uses a shorter Roux limb than standard because he does not like redundant Roux loops.↗
▶Ep 13 · 30:34
clinicalYamataka uses a shorter Roux limb than standard because he does not like redundant Roux loops.↗
Biliary Atresia Part II
▶Ep 14 · 11:15
clinicalTokyo protocol: start prednisone 4mg/kg/day after CRP normalizes post-op, taper over 15 days (4→3→2→1→0.5mg/kg, 3 days each), return to higher dose if stool becomes acholic↗
▶Ep 14 · 11:15
clinicalTokyo protocol: start prednisone 4mg/kg/day after CRP normalizes post-op, taper over 15 days (4→3→2→1→0.5mg/kg, 3 days each), return to higher dose if stool becomes acholic↗
▶Ep 14 · 18:10
opinionSTART trial started steroids on post-op day 1, whereas Tokyo and King's protocols wait 4-7 days until CRP normalizes—this timing difference may affect safety profile↗
▶Ep 14 · 18:10
quoteI think immediately after operation, starting a steroid is, I think, a bit dangerous.↗
▶Ep 14 · 18:10
quoteI think immediately after operation, starting a steroid is, I think, a bit dangerous.↗
▶Ep 14 · 18:10
opinionSTART trial started steroids on post-op day 1, whereas Tokyo and King's protocols wait 4-7 days until CRP normalizes—this timing difference may affect safety profile↗
▶Ep 14 · 19:05
clinicalEarly post-operative cholangitis is a bad prognostic sign for long-term native liver survival↗
▶Ep 14 · 19:05
clinicalEarly post-operative cholangitis is a bad prognostic sign for long-term native liver survival↗
▶Ep 14 · 19:05
quoteOnce patients have early cholangitis, I think that is a bad sign for long-term native liver survival.↗
▶Ep 14 · 19:05
quoteOnce patients have early cholangitis, I think that is a bad sign for long-term native liver survival.↗
▶Ep 14 · 23:09
clinicalFor cystic biliary atresia with visible intrahepatic ducts on cholangiogram, prognosis is better even in late presenters↗
▶Ep 14 · 23:09
clinicalTokyo approach to late presenters: decision based on timing of acholic stool onset, not chronological age—if acholic from birth, consider primary transplant; if yellow stool for first month of life, proceed to Kasai even at 100 days↗
▶Ep 14 · 23:09
clinicalFor cystic biliary atresia with visible intrahepatic ducts on cholangiogram, prognosis is better even in late presenters↗
▶Ep 14 · 23:09
clinicalTokyo approach to late presenters: decision based on timing of acholic stool onset, not chronological age—if acholic from birth, consider primary transplant; if yellow stool for first month of life, proceed to Kasai even at 100 days↗
▶Ep 14 · 26:19
quoteI think the most important thing is, I think the duration of the creamy stool is strongly related to the outcome in my department.↗
▶Ep 14 · 26:19
clinicalTokyo data shows age at Kasai is not significantly related to outcome; duration of acholic stool (disease duration) is the most important prognostic factor↗
▶Ep 14 · 26:19
quoteI think the most important thing is, I think the duration of the creamy stool is strongly related to the outcome in my department.↗
▶Ep 14 · 26:19
clinicalTokyo data shows age at Kasai is not significantly related to outcome; duration of acholic stool (disease duration) is the most important prognostic factor↗
▶Ep 14 · 28:51
clinicalTokyo cholangitis protocol: intensive IV antibiotics until CRP and white count normalize, then steroids; revision Kasai not performed due to poor outcomes↗
▶Ep 14 · 28:51
clinicalTokyo cholangitis protocol: intensive IV antibiotics until CRP and white count normalize, then steroids; revision Kasai not performed due to poor outcomes↗