Anfleur von Hall

20 timestamped statements across 1 collection — auto-found in recorded discussions, each timestamp jumps to the exact moment.

Featured statements

▶ Ep 33 · 0:20
The SEP CA trial stands for intralesional steroid injections to prevent refractory strictures in patients with esophageal atresia and is an international multi-center randomized control trial.
quote · Esophageal Atresia
▶ Ep 33 · 1:45
It is thought that these steroids inhibit the formation of collagen, enhances its breakdown, and decreases the fibrotic healing.
quote · Esophageal Atresia

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Esophageal Atresia 20 entries

STEPS-EA trial: Esophageal Atresia

▶ Ep 33 · 0:00
quote Hello, my name is Anfleur von Hall, and I'm one of the coordinating investigators of the SECA trial. ↗
▶ Ep 33 · 0:00
clinical The STEPS-EA trial is an international multi-center randomized control trial initiated by the Sophia Children's Hospital in Rotterdam with cooperation from the European Reference Network ERICA. ↗
▶ Ep 33 · 0:20
quote The SEP CA trial stands for intralesional steroid injections to prevent refractory strictures in patients with esophageal atresia and is an international multi-center randomized control trial. ↗
▶ Ep 33 · 0:40
clinical The standard treatment for esophageal atresia is surgery with an end-to-end anastomosis to restore continuity. ↗
▶ Ep 33 · 0:55
quote stricture formation remains the most frequent post-operative complication in more than half of the cases. ↗
▶ Ep 33 · 0:55
epidemiological Stricture formation remains the most frequent post-operative complication in more than half of esophageal atresia cases. ↗
▶ Ep 33 · 1:10
clinical The current standard treatment for esophageal stricture is endoscopic dilatation either by bouginage or by balloon dilatation. ↗
▶ Ep 33 · 1:20
clinical Worldwide, balloon dilatation is most frequently used for esophageal strictures, which is why it has been chosen as the standard procedure for the intervention in this study. ↗
▶ Ep 33 · 1:35
clinical Intralesional steroid injections are an adjuvant treatment to endoscopic dilatation, where mostly triamcinolone is used. ↗
▶ Ep 33 · 1:45
quote It is thought that these steroids inhibit the formation of collagen, enhances its breakdown, and decreases the fibrotic healing. ↗
▶ Ep 33 · 1:45
clinical Steroids are thought to inhibit the formation of collagen, enhance its breakdown, and decrease fibrotic healing, thereby inhibiting scar formation and making stenosis less likely to recur. ↗
▶ Ep 33 · 1:55
clinical Each of the four quadrants of the stricture will be injected with steroid. ↗
▶ Ep 33 · 2:00
clinical The trial will investigate three main topics: effectiveness, safety, and cost-effectiveness of intralesional steroid injection. ↗
▶ Ep 33 · 2:10
clinical 110 children born with esophageal atresia are needed to prove the effectiveness of the steroid injection. ↗
▶ Ep 33 · 2:18
clinical Study group A will be injected with triamcinolone and then undergo balloon dilatation, while study group B will only undergo balloon dilatation as part of standard of care. ↗
▶ Ep 33 · 2:35
clinical All patients undergo an esophagram prior to dilatation as part of standard of care. ↗
▶ Ep 33 · 2:42
clinical A second esophagram will be performed to objectify the effectiveness of the intervention on the length and diameter of the stricture. ↗
▶ Ep 33 · 2:52
clinical Physical length and weight will be measured at 4 time points throughout the 6-month study period to investigate possible systemic side effects of a single dose steroid injection. ↗
▶ Ep 33 · 3:03
clinical At the end of the follow-up period, a small scale hair sample will be collected to measure cortisol levels to investigate possible systemic effects and safety of the intralesional steroid injection. ↗
▶ Ep 33 · 3:13
clinical During the follow-up period, parents will be asked to fill out an online questionnaire about disease-related expenses and dysphagia. ↗