Andrew Reddington

176 timestamped statements across 2 collections — auto-found in recorded discussions, each timestamp jumps to the exact moment.

Single Ventricle / HLHS · guest expert

Featured diaries

▶ Ep 2 · 6:36
if ever the right ventricle, which is traditionally thought to be the somewhat weaker ventricle, was gonna expose itself as a weaker ventricle, it would be in the fontan circulation
quote · Hypoplastic Left Heart Syndrome
▶ Ep 2 · 6:36
if ever the right ventricle, which is traditionally thought to be the somewhat weaker ventricle, was gonna expose itself as a weaker ventricle, it would be in the fontan circulation
quote · Hypoplastic Left Heart Syndrome
▶ Ep 13 · 6:36
if ever the right ventricle, which is traditionally thought to be the somewhat weaker ventricle, was gonna expose itself as a weaker ventricle, it would be in the fontan circulation
quote · Single Ventricle / HLHS
▶ Ep 13 · 6:36
if ever the right ventricle, which is traditionally thought to be the somewhat weaker ventricle, was gonna expose itself as a weaker ventricle, it would be in the fontan circulation
quote · Single Ventricle / HLHS

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Hypoplastic Left Heart Syndrome 88 entries

How Does the Blood Go Round in Single Ventricles and Fontans? New Horizons in...

▶ Ep 2 · 1:20
quote how does the blood go round? ↗
▶ Ep 2 · 1:20
quote how does the blood go round? ↗
▶ Ep 2 · 2:24
quote breathing makes the blood go round ↗
▶ Ep 2 · 2:24
quote breathing makes the blood go round ↗
▶ Ep 2 · 2:43
clinical 40-50% of cardiac output at baseline in Fontan patients is driven directly by the work of breathing ↗
▶ Ep 2 · 2:43
clinical 40-50% of cardiac output at baseline in Fontan patients is driven directly by the work of breathing ↗
▶ Ep 2 · 3:14
clinical Negative mean airway pressure during normal ventilation draws blood into the Fontan circuit ↗
▶ Ep 2 · 3:14
clinical Negative mean airway pressure during normal ventilation draws blood into the Fontan circuit ↗
▶ Ep 2 · 3:25
clinical Valsalva maneuver with mean airway pressure elevated to 20 cm H2O cuts off spontaneous respiratory flow, leaving only tiny flow with ventricular systole ↗
▶ Ep 2 · 3:25
clinical Valsalva maneuver with mean airway pressure elevated to 20 cm H2O cuts off spontaneous respiratory flow, leaving only tiny flow with ventricular systole ↗
▶ Ep 2 · 3:49
quote the fontan circulation is one of the few situations where constipation can be fatal ↗
▶ Ep 2 · 3:49
quote the fontan circulation is one of the few situations where constipation can be fatal ↗
▶ Ep 2 · 4:01
clinical Low pulmonary vascular resistance is a prerequisite for good Fontan outcome ↗
▶ Ep 2 · 4:01
clinical Low pulmonary vascular resistance is a prerequisite for good Fontan outcome ↗
▶ Ep 2 · 4:52
clinical In normal individuals, nitric oxide does not reduce pulmonary vascular resistance because the pulmonary vascular bed is maximally vasodilated ↗
▶ Ep 2 · 4:52
quote in you and I, if I give you nitric oxide, the pulmonary vascular resistance doesn't fall because we're maximally vasodilated in the pulmonary vascular bed ↗
▶ Ep 2 · 4:52
clinical In normal individuals, nitric oxide does not reduce pulmonary vascular resistance because the pulmonary vascular bed is maximally vasodilated ↗
▶ Ep 2 · 4:52
quote in you and I, if I give you nitric oxide, the pulmonary vascular resistance doesn't fall because we're maximally vasodilated in the pulmonary vascular bed ↗
▶ Ep 2 · 5:01
clinical Nitric oxide produced a statistically and physiologically significant fall in pulmonary vascular resistance of about 1 index wood unit in teenage Fontan patients ↗
▶ Ep 2 · 5:01
clinical Nitric oxide produced a statistically and physiologically significant fall in pulmonary vascular resistance of about 1 index wood unit in teenage Fontan patients ↗
▶ Ep 2 · 5:39
clinical Only half of teenage Fontan patients showed benefit from nitric oxide ↗
▶ Ep 2 · 5:39
clinical Only half of teenage Fontan patients showed benefit from nitric oxide ↗
▶ Ep 2 · 6:00
opinion If only half of Fontan patients benefit from nitric oxide, they are unlikely to further benefit from PDE5 inhibitors ↗
▶ Ep 2 · 6:00
opinion If only half of Fontan patients benefit from nitric oxide, they are unlikely to further benefit from PDE5 inhibitors ↗
▶ Ep 2 · 6:36
quote if ever the right ventricle, which is traditionally thought to be the somewhat weaker ventricle, was gonna expose itself as a weaker ventricle, it would be in the fontan circulation ↗
▶ Ep 2 · 6:36
quote if ever the right ventricle, which is traditionally thought to be the somewhat weaker ventricle, was gonna expose itself as a weaker ventricle, it would be in the fontan circulation ↗
▶ Ep 2 · 6:54
host_summary CHOP data showed no difference in outcomes in the first 10 years after Fontan between hypoplastic left heart syndrome and systemic left ventricle patients ↗
▶ Ep 2 · 6:54
epidemiological CHOP data showed no difference in outcomes in the first 10 years after Fontan between hypoplastic left heart syndrome and systemic left ventricle patients ↗
▶ Ep 2 · 7:21
epidemiological Boston data showed patients born with systemic left ventricle with normally related great vessels or single right ventricle do better than all other diagnoses ↗
▶ Ep 2 · 7:21
host_summary Boston data showed patients born with systemic left ventricle with normally related great vessels or single right ventricle do better than all other diagnoses ↗
▶ Ep 2 · 7:40
host_summary Melbourne group data showed right ventricular dominance is a risk factor if present at birth, but after surviving the first couple of years post-Fontan, survival curves are essentially identical regardless of ventricular morphology ↗
▶ Ep 2 · 7:40
epidemiological Melbourne group data showed right ventricular dominance is a risk factor if present at birth, but after surviving the first couple of years post-Fontan, survival curves are essentially identical regardless of ventricular morphology ↗
▶ Ep 2 · 8:22
clinical The systemic ventricle in Fontan circulation is hypercontractile to match its increased afterload ↗
▶ Ep 2 · 8:22
clinical The systemic ventricle in Fontan circulation is hypercontractile to match its increased afterload ↗
▶ Ep 2 · 8:37
host_summary Force-frequency relationships in systemic right and left ventricles in univentricular circulation outperformed normal ventricles ↗
▶ Ep 2 · 8:37
clinical Force-frequency relationships in systemic right and left ventricles in univentricular circulation outperformed normal ventricles ↗
▶ Ep 2 · 9:03
clinical End-systolic elastance in Fontan patients is orders of magnitude higher than normals and even greater than in systemic right ventricle of Mustard patients ↗
▶ Ep 2 · 9:03
host_summary End-systolic elastance in Fontan patients is orders of magnitude higher than normals and even greater than in systemic right ventricle of Mustard patients ↗
▶ Ep 2 · 9:21
quote these are strong ventricles that are pumping against, albeit a high resistance ↗
▶ Ep 2 · 9:21
quote these are strong ventricles that are pumping against, albeit a high resistance ↗
▶ Ep 2 · 9:29
clinical Arterial elastance is high in Fontan patients but relatively well coupled to ventricular elastance ↗
▶ Ep 2 · 9:29
clinical The primary problem in Fontan ventricles is in diastole, not systole ↗
▶ Ep 2 · 9:29
clinical The primary problem in Fontan ventricles is in diastole, not systole ↗
▶ Ep 2 · 9:29
clinical Arterial elastance is high in Fontan patients but relatively well coupled to ventricular elastance ↗
▶ Ep 2 · 10:14
clinical In early post-Fontan course, it is early diastole (E wave) that is affected, not late diastole (A wave), with virtual abolishment of early rapid filling ↗
▶ Ep 2 · 10:14
clinical In early post-Fontan course, it is early diastole (E wave) that is affected, not late diastole (A wave), with virtual abolishment of early rapid filling ↗
▶ Ep 2 · 10:43
clinical Time constant of relaxation and isovolumic relaxation time are prolonged in early post-Fontan patients, indicative of impaired relaxation ↗
▶ Ep 2 · 10:43
clinical Time constant of relaxation and isovolumic relaxation time are prolonged in early post-Fontan patients, indicative of impaired relaxation ↗
▶ Ep 2 · 10:56
clinical Impaired early relaxation is due to incoordinate wall motion during isovolumic relaxation, with post-systolic shortening of one part of the ventricle causing another part to move outward ↗
▶ Ep 2 · 10:56
clinical Impaired early relaxation is due to incoordinate wall motion during isovolumic relaxation, with post-systolic shortening of one part of the ventricle causing another part to move outward ↗
▶ Ep 2 · 11:58
host_summary MRI tagging showed some segments of Fontan ventricular wall were 180 degrees out of phase with other parts, in systole when rest of ventricle was in diastole ↗
▶ Ep 2 · 11:58
clinical MRI tagging showed some segments of Fontan ventricular wall were 180 degrees out of phase with other parts, in systole when rest of ventricle was in diastole ↗
▶ Ep 2 · 12:23
clinical Longer isovolumic relaxation time correlates with longer hospital stay immediately after Fontan operation ↗
▶ Ep 2 · 12:23
clinical Longer isovolumic relaxation time correlates with longer hospital stay immediately after Fontan operation ↗
▶ Ep 2 · 13:03
clinical Late post-Fontan patients can develop pseudonormalized filling pattern (E > A) due to rising left atrial pressure despite persistent incoordinate relaxation ↗
▶ Ep 2 · 13:03
clinical Late post-Fontan patients can develop pseudonormalized filling pattern (E > A) due to rising left atrial pressure despite persistent incoordinate relaxation ↗
▶ Ep 2 · 13:36
clinical In normal individuals, left ventricular end-diastolic pressure rises by about 2 mmHg per decade after age 30 ↗
▶ Ep 2 · 13:36
clinical In normal individuals, left ventricular end-diastolic pressure rises by about 2 mmHg per decade after age 30 ↗
▶ Ep 2 · 14:18
clinical Eight-year follow-up of Fontan patients showed maintained incoordinate relaxation, shortened IVRT suggesting rising left atrial pressure, and faster E wave deceleration suggesting falling compliance ↗
▶ Ep 2 · 14:18
host_summary Eight-year follow-up of Fontan patients showed maintained incoordinate relaxation, shortened IVRT suggesting rising left atrial pressure, and faster E wave deceleration suggesting falling compliance ↗
▶ Ep 2 · 14:47
clinical Diastolic compliance of Fontan ventricles (predominantly left ventricles) is highly abnormal, unlike Mustard systemic right ventricles where diastolic compliance is not a problem ↗
▶ Ep 2 · 14:47
host_summary Diastolic compliance of Fontan ventricles (predominantly left ventricles) is highly abnormal, unlike Mustard systemic right ventricles where diastolic compliance is not a problem ↗
▶ Ep 2 · 15:06
quote if you can't fill in early diastole and you can't fill in late diastole, you're not gonna fill at all and you have a low stroke volume and a low cardiac output ↗
▶ Ep 2 · 15:06
quote if you can't fill in early diastole and you can't fill in late diastole, you're not gonna fill at all and you have a low stroke volume and a low cardiac output ↗
▶ Ep 2 · 15:33
clinical Fontan patients with high diastolic stiffness may have low end-diastolic pressure because reduced preload causes the ventricle to become smaller and pressure to fall down the pressure-volume curve ↗
▶ Ep 2 · 15:33
clinical Fontan patients with high diastolic stiffness may have low end-diastolic pressure because reduced preload causes the ventricle to become smaller and pressure to fall down the pressure-volume curve ↗
▶ Ep 2 · 15:41
quote in the presence of really profoundly abnormal ventricular compliance, these patients can have a normal left ventricular and diastolic pressure ↗
▶ Ep 2 · 15:41
quote in the presence of really profoundly abnormal ventricular compliance, these patients can have a normal left ventricular and diastolic pressure ↗
▶ Ep 2 · 17:37
clinical Bench pressing 500 pounds essentially cuts off pulmonary blood flow in Fontan patients ↗
▶ Ep 2 · 17:37
clinical Bench pressing 500 pounds essentially cuts off pulmonary blood flow in Fontan patients ↗
▶ Ep 2 · 18:13
opinion Sustained Valsalva maneuvers may be particularly disadvantageous in old atrio-pulmonary Fontans due to direct effects on atrial stretch and potential for chronic atrial arrhythmias ↗
▶ Ep 2 · 18:13
opinion Sustained Valsalva maneuvers may be particularly disadvantageous in old atrio-pulmonary Fontans due to direct effects on atrial stretch and potential for chronic atrial arrhythmias ↗
▶ Ep 2 · 20:04
clinical PHN data at 10-12 years post-Fontan showed systemic right ventricles had far more patients with increased E/E' ratio (indicating increased stiffness) compared to systemic left ventricles ↗
▶ Ep 2 · 20:04
host_summary PHN data at 10-12 years post-Fontan showed systemic right ventricles had far more patients with increased E/E' ratio (indicating increased stiffness) compared to systemic left ventricles ↗
▶ Ep 2 · 21:58
clinical Rise in end-diastolic pressure in normal individuals is more rapid with hypertension, diabetes, other risk factors, and ventricular volume load such as AV valve or aortic regurgitation ↗
▶ Ep 2 · 21:58
clinical Rise in end-diastolic pressure in normal individuals is more rapid with hypertension, diabetes, other risk factors, and ventricular volume load such as AV valve or aortic regurgitation ↗
▶ Ep 2 · 22:33
clinical Fontan patients frequently have some degree of volume load and have had volume load for the first few years of life ↗
▶ Ep 2 · 22:33
clinical Fontan patients frequently have some degree of volume load and have had volume load for the first few years of life ↗
▶ Ep 2 · 22:44
clinical All Fontan patients have very raised arterial impedance and systemic vascular resistance ↗
▶ Ep 2 · 22:44
clinical All Fontan patients have very raised arterial impedance and systemic vascular resistance ↗
▶ Ep 2 · 23:01
host_summary Recent conductance catheter work from the Netherlands shows a tight relationship between arterial elastance and ventricular end-diastolic pressure ↗
▶ Ep 2 · 23:01
clinical Recent conductance catheter work from the Netherlands shows a tight relationship between arterial elastance and ventricular end-diastolic pressure ↗
▶ Ep 2 · 23:18
opinion There is no evidence-based role for ACE inhibition or arterial vasodilators in short-term Fontan management, as systemic vasodilation drops cardiac output ↗
▶ Ep 2 · 23:18
opinion There is no evidence-based role for ACE inhibition or arterial vasodilators in short-term Fontan management, as systemic vasodilation drops cardiac output ↗
▶ Ep 2 · 23:38
opinion Management of left ventricular end-diastolic pressure, fibrosis, and vascular biology have real potential as therapeutic targets in long-term Fontan management ↗
▶ Ep 2 · 23:38
opinion Management of left ventricular end-diastolic pressure, fibrosis, and vascular biology have real potential as therapeutic targets in long-term Fontan management ↗
▶ Ep 2 · 23:58
opinion Understanding the impact of long-term therapies for diastolic dysfunction will require 10-20 years of follow-up ↗
▶ Ep 2 · 23:58
opinion Understanding the impact of long-term therapies for diastolic dysfunction will require 10-20 years of follow-up ↗
Single Ventricle / HLHS 88 entries

How Does the Blood Go Round in Single Ventricles and Fontans? New Horizons in...

▶ Ep 13 · 1:20
quote how does the blood go round? ↗
▶ Ep 13 · 1:20
quote how does the blood go round? ↗
▶ Ep 13 · 2:24
quote breathing makes the blood go round ↗
▶ Ep 13 · 2:24
quote breathing makes the blood go round ↗
▶ Ep 13 · 2:43
clinical 40-50% of cardiac output at baseline in Fontan patients is driven directly by the work of breathing ↗
▶ Ep 13 · 2:43
clinical 40-50% of cardiac output at baseline in Fontan patients is driven directly by the work of breathing ↗
▶ Ep 13 · 3:14
clinical Negative mean airway pressure during normal ventilation draws blood into the Fontan circuit ↗
▶ Ep 13 · 3:14
clinical Negative mean airway pressure during normal ventilation draws blood into the Fontan circuit ↗
▶ Ep 13 · 3:25
clinical Valsalva maneuver with mean airway pressure elevated to 20 cm H2O cuts off spontaneous respiratory flow, leaving only tiny flow with ventricular systole ↗
▶ Ep 13 · 3:25
clinical Valsalva maneuver with mean airway pressure elevated to 20 cm H2O cuts off spontaneous respiratory flow, leaving only tiny flow with ventricular systole ↗
▶ Ep 13 · 3:49
quote the fontan circulation is one of the few situations where constipation can be fatal ↗
▶ Ep 13 · 3:49
quote the fontan circulation is one of the few situations where constipation can be fatal ↗
▶ Ep 13 · 4:01
clinical Low pulmonary vascular resistance is a prerequisite for good Fontan outcome ↗
▶ Ep 13 · 4:01
clinical Low pulmonary vascular resistance is a prerequisite for good Fontan outcome ↗
▶ Ep 13 · 4:52
clinical In normal individuals, nitric oxide does not reduce pulmonary vascular resistance because the pulmonary vascular bed is maximally vasodilated ↗
▶ Ep 13 · 4:52
quote in you and I, if I give you nitric oxide, the pulmonary vascular resistance doesn't fall because we're maximally vasodilated in the pulmonary vascular bed ↗
▶ Ep 13 · 4:52
quote in you and I, if I give you nitric oxide, the pulmonary vascular resistance doesn't fall because we're maximally vasodilated in the pulmonary vascular bed ↗
▶ Ep 13 · 4:52
clinical In normal individuals, nitric oxide does not reduce pulmonary vascular resistance because the pulmonary vascular bed is maximally vasodilated ↗
▶ Ep 13 · 5:01
clinical Nitric oxide produced a statistically and physiologically significant fall in pulmonary vascular resistance of about 1 index wood unit in teenage Fontan patients ↗
▶ Ep 13 · 5:01
clinical Nitric oxide produced a statistically and physiologically significant fall in pulmonary vascular resistance of about 1 index wood unit in teenage Fontan patients ↗
▶ Ep 13 · 5:39
clinical Only half of teenage Fontan patients showed benefit from nitric oxide ↗
▶ Ep 13 · 5:39
clinical Only half of teenage Fontan patients showed benefit from nitric oxide ↗
▶ Ep 13 · 6:00
opinion If only half of Fontan patients benefit from nitric oxide, they are unlikely to further benefit from PDE5 inhibitors ↗
▶ Ep 13 · 6:00
opinion If only half of Fontan patients benefit from nitric oxide, they are unlikely to further benefit from PDE5 inhibitors ↗
▶ Ep 13 · 6:36
quote if ever the right ventricle, which is traditionally thought to be the somewhat weaker ventricle, was gonna expose itself as a weaker ventricle, it would be in the fontan circulation ↗
▶ Ep 13 · 6:36
quote if ever the right ventricle, which is traditionally thought to be the somewhat weaker ventricle, was gonna expose itself as a weaker ventricle, it would be in the fontan circulation ↗
▶ Ep 13 · 6:54
host_summary CHOP data showed no difference in outcomes in the first 10 years after Fontan between hypoplastic left heart syndrome and systemic left ventricle patients ↗
▶ Ep 13 · 6:54
epidemiological CHOP data showed no difference in outcomes in the first 10 years after Fontan between hypoplastic left heart syndrome and systemic left ventricle patients ↗
▶ Ep 13 · 7:21
host_summary Boston data showed patients born with systemic left ventricle with normally related great vessels or single right ventricle do better than all other diagnoses ↗
▶ Ep 13 · 7:21
epidemiological Boston data showed patients born with systemic left ventricle with normally related great vessels or single right ventricle do better than all other diagnoses ↗
▶ Ep 13 · 7:40
epidemiological Melbourne group data showed right ventricular dominance is a risk factor if present at birth, but after surviving the first couple of years post-Fontan, survival curves are essentially identical regardless of ventricular morphology ↗
▶ Ep 13 · 7:40
host_summary Melbourne group data showed right ventricular dominance is a risk factor if present at birth, but after surviving the first couple of years post-Fontan, survival curves are essentially identical regardless of ventricular morphology ↗
▶ Ep 13 · 8:22
clinical The systemic ventricle in Fontan circulation is hypercontractile to match its increased afterload ↗
▶ Ep 13 · 8:22
clinical The systemic ventricle in Fontan circulation is hypercontractile to match its increased afterload ↗
▶ Ep 13 · 8:37
clinical Force-frequency relationships in systemic right and left ventricles in univentricular circulation outperformed normal ventricles ↗
▶ Ep 13 · 8:37
host_summary Force-frequency relationships in systemic right and left ventricles in univentricular circulation outperformed normal ventricles ↗
▶ Ep 13 · 9:03
clinical End-systolic elastance in Fontan patients is orders of magnitude higher than normals and even greater than in systemic right ventricle of Mustard patients ↗
▶ Ep 13 · 9:03
host_summary End-systolic elastance in Fontan patients is orders of magnitude higher than normals and even greater than in systemic right ventricle of Mustard patients ↗
▶ Ep 13 · 9:21
quote these are strong ventricles that are pumping against, albeit a high resistance ↗
▶ Ep 13 · 9:21
quote these are strong ventricles that are pumping against, albeit a high resistance ↗
▶ Ep 13 · 9:29
clinical Arterial elastance is high in Fontan patients but relatively well coupled to ventricular elastance ↗
▶ Ep 13 · 9:29
clinical Arterial elastance is high in Fontan patients but relatively well coupled to ventricular elastance ↗
▶ Ep 13 · 9:29
clinical The primary problem in Fontan ventricles is in diastole, not systole ↗
▶ Ep 13 · 9:29
clinical The primary problem in Fontan ventricles is in diastole, not systole ↗
▶ Ep 13 · 10:14
clinical In early post-Fontan course, it is early diastole (E wave) that is affected, not late diastole (A wave), with virtual abolishment of early rapid filling ↗
▶ Ep 13 · 10:14
clinical In early post-Fontan course, it is early diastole (E wave) that is affected, not late diastole (A wave), with virtual abolishment of early rapid filling ↗
▶ Ep 13 · 10:43
clinical Time constant of relaxation and isovolumic relaxation time are prolonged in early post-Fontan patients, indicative of impaired relaxation ↗
▶ Ep 13 · 10:43
clinical Time constant of relaxation and isovolumic relaxation time are prolonged in early post-Fontan patients, indicative of impaired relaxation ↗
▶ Ep 13 · 10:56
clinical Impaired early relaxation is due to incoordinate wall motion during isovolumic relaxation, with post-systolic shortening of one part of the ventricle causing another part to move outward ↗
▶ Ep 13 · 10:56
clinical Impaired early relaxation is due to incoordinate wall motion during isovolumic relaxation, with post-systolic shortening of one part of the ventricle causing another part to move outward ↗
▶ Ep 13 · 11:58
host_summary MRI tagging showed some segments of Fontan ventricular wall were 180 degrees out of phase with other parts, in systole when rest of ventricle was in diastole ↗
▶ Ep 13 · 11:58
clinical MRI tagging showed some segments of Fontan ventricular wall were 180 degrees out of phase with other parts, in systole when rest of ventricle was in diastole ↗
▶ Ep 13 · 12:23
clinical Longer isovolumic relaxation time correlates with longer hospital stay immediately after Fontan operation ↗
▶ Ep 13 · 12:23
clinical Longer isovolumic relaxation time correlates with longer hospital stay immediately after Fontan operation ↗
▶ Ep 13 · 13:03
clinical Late post-Fontan patients can develop pseudonormalized filling pattern (E > A) due to rising left atrial pressure despite persistent incoordinate relaxation ↗
▶ Ep 13 · 13:03
clinical Late post-Fontan patients can develop pseudonormalized filling pattern (E > A) due to rising left atrial pressure despite persistent incoordinate relaxation ↗
▶ Ep 13 · 13:36
clinical In normal individuals, left ventricular end-diastolic pressure rises by about 2 mmHg per decade after age 30 ↗
▶ Ep 13 · 13:36
clinical In normal individuals, left ventricular end-diastolic pressure rises by about 2 mmHg per decade after age 30 ↗
▶ Ep 13 · 14:18
clinical Eight-year follow-up of Fontan patients showed maintained incoordinate relaxation, shortened IVRT suggesting rising left atrial pressure, and faster E wave deceleration suggesting falling compliance ↗
▶ Ep 13 · 14:18
host_summary Eight-year follow-up of Fontan patients showed maintained incoordinate relaxation, shortened IVRT suggesting rising left atrial pressure, and faster E wave deceleration suggesting falling compliance ↗
▶ Ep 13 · 14:47
host_summary Diastolic compliance of Fontan ventricles (predominantly left ventricles) is highly abnormal, unlike Mustard systemic right ventricles where diastolic compliance is not a problem ↗
▶ Ep 13 · 14:47
clinical Diastolic compliance of Fontan ventricles (predominantly left ventricles) is highly abnormal, unlike Mustard systemic right ventricles where diastolic compliance is not a problem ↗
▶ Ep 13 · 15:06
quote if you can't fill in early diastole and you can't fill in late diastole, you're not gonna fill at all and you have a low stroke volume and a low cardiac output ↗
▶ Ep 13 · 15:06
quote if you can't fill in early diastole and you can't fill in late diastole, you're not gonna fill at all and you have a low stroke volume and a low cardiac output ↗
▶ Ep 13 · 15:33
clinical Fontan patients with high diastolic stiffness may have low end-diastolic pressure because reduced preload causes the ventricle to become smaller and pressure to fall down the pressure-volume curve ↗
▶ Ep 13 · 15:33
clinical Fontan patients with high diastolic stiffness may have low end-diastolic pressure because reduced preload causes the ventricle to become smaller and pressure to fall down the pressure-volume curve ↗
▶ Ep 13 · 15:41
quote in the presence of really profoundly abnormal ventricular compliance, these patients can have a normal left ventricular and diastolic pressure ↗
▶ Ep 13 · 15:41
quote in the presence of really profoundly abnormal ventricular compliance, these patients can have a normal left ventricular and diastolic pressure ↗
▶ Ep 13 · 17:37
clinical Bench pressing 500 pounds essentially cuts off pulmonary blood flow in Fontan patients ↗
▶ Ep 13 · 17:37
clinical Bench pressing 500 pounds essentially cuts off pulmonary blood flow in Fontan patients ↗
▶ Ep 13 · 18:13
opinion Sustained Valsalva maneuvers may be particularly disadvantageous in old atrio-pulmonary Fontans due to direct effects on atrial stretch and potential for chronic atrial arrhythmias ↗
▶ Ep 13 · 18:13
opinion Sustained Valsalva maneuvers may be particularly disadvantageous in old atrio-pulmonary Fontans due to direct effects on atrial stretch and potential for chronic atrial arrhythmias ↗
▶ Ep 13 · 20:04
clinical PHN data at 10-12 years post-Fontan showed systemic right ventricles had far more patients with increased E/E' ratio (indicating increased stiffness) compared to systemic left ventricles ↗
▶ Ep 13 · 20:04
host_summary PHN data at 10-12 years post-Fontan showed systemic right ventricles had far more patients with increased E/E' ratio (indicating increased stiffness) compared to systemic left ventricles ↗
▶ Ep 13 · 21:58
clinical Rise in end-diastolic pressure in normal individuals is more rapid with hypertension, diabetes, other risk factors, and ventricular volume load such as AV valve or aortic regurgitation ↗
▶ Ep 13 · 21:58
clinical Rise in end-diastolic pressure in normal individuals is more rapid with hypertension, diabetes, other risk factors, and ventricular volume load such as AV valve or aortic regurgitation ↗
▶ Ep 13 · 22:33
clinical Fontan patients frequently have some degree of volume load and have had volume load for the first few years of life ↗
▶ Ep 13 · 22:33
clinical Fontan patients frequently have some degree of volume load and have had volume load for the first few years of life ↗
▶ Ep 13 · 22:44
clinical All Fontan patients have very raised arterial impedance and systemic vascular resistance ↗
▶ Ep 13 · 22:44
clinical All Fontan patients have very raised arterial impedance and systemic vascular resistance ↗
▶ Ep 13 · 23:01
clinical Recent conductance catheter work from the Netherlands shows a tight relationship between arterial elastance and ventricular end-diastolic pressure ↗
▶ Ep 13 · 23:01
host_summary Recent conductance catheter work from the Netherlands shows a tight relationship between arterial elastance and ventricular end-diastolic pressure ↗
▶ Ep 13 · 23:18
opinion There is no evidence-based role for ACE inhibition or arterial vasodilators in short-term Fontan management, as systemic vasodilation drops cardiac output ↗
▶ Ep 13 · 23:18
opinion There is no evidence-based role for ACE inhibition or arterial vasodilators in short-term Fontan management, as systemic vasodilation drops cardiac output ↗
▶ Ep 13 · 23:38
opinion Management of left ventricular end-diastolic pressure, fibrosis, and vascular biology have real potential as therapeutic targets in long-term Fontan management ↗
▶ Ep 13 · 23:38
opinion Management of left ventricular end-diastolic pressure, fibrosis, and vascular biology have real potential as therapeutic targets in long-term Fontan management ↗
▶ Ep 13 · 23:58
opinion Understanding the impact of long-term therapies for diastolic dysfunction will require 10-20 years of follow-up ↗
▶ Ep 13 · 23:58
opinion Understanding the impact of long-term therapies for diastolic dysfunction will require 10-20 years of follow-up ↗