Dr. Adriana Dekirmendjian - Best of the Best in Pediatric Surgery 2025
▶Ep 33 · 1:15
quotecongenital diaphragmatic hernia is a relatively rare birth defect with significant short as well as long-term sequele↗
▶Ep 33 · 1:30
epidemiologicalA systematic review by the study group demonstrated that the incidence of CDH varies significantly between regions and populations with a global overall incidence of 2.3 per 10,000 births.↗
▶Ep 33 · 1:35
quotethe incidence of CDH varies significantly between regions and populations with a global overall incidence of 2.3 per 10,000 births↗
▶Ep 33 · 1:45
epidemiologicalThere are no national Canadian epidemiological studies examining CDH prior to this study.↗
▶Ep 33 · 2:05
clinicalThe study utilized the Canadian Institute of Health Information discharge abstract database from 2006 to 2020 and Quebec's Med Echo database from 2008 to 2020.↗
▶Ep 33 · 2:30
clinicalCDH cases were identified using the validated ICD-10 code Q79.0.↗
▶Ep 33 · 2:38
clinicalThe CIHI database included both live and stillbirths, whereas the Med Echo database only included live births.↗
▶Ep 33 · 2:48
clinicalTerminations were excluded from both databases.↗
▶Ep 33 · 2:52
clinicalThere was no distinction between isolated versus complex CDH nor laterality in the databases.↗
▶Ep 33 · 3:35
epidemiologicalThe Canadian incidence of CDH from 2006 to 2020 was 2.71 per 10,000 births.↗
▶Ep 33 · 3:35
quotethe Canadian incidence of CDH from 2006 to 2020 was 2.71 per 10,000 births↗
▶Ep 33 · 3:45
quoteManitoba had the highest incidence of CDH, followed by Nova Scotia and Sawan↗
▶Ep 33 · 3:45
epidemiologicalManitoba had the highest incidence of CDH, followed by Nova Scotia and Saskatchewan.↗
▶Ep 33 · 3:53
epidemiologicalManitoba had a significantly higher incidence of CDH compared to Ontario with an incidence rate ratio of 1.33.↗
▶Ep 33 · 4:05
epidemiological58% of CDH patients were assigned male sex at birth.↗
▶Ep 33 · 4:15
epidemiologicalThere was no significant difference in CDH incidence over time from 2006 to 2020.↗
▶Ep 33 · 4:25
epidemiologicalAdvanced maternal age, specifically maternal age 40 plus, was associated with an increased rate of CDH with an incidence rate ratio of 1.68.↗
▶Ep 33 · 4:40
clinicalThe study was limited by use of aggregate versus patient level data, preventing control for various covariates and determination of independence of associations.↗
▶Ep 33 · 4:52
clinicalAdministrative data is limited in terms of what is collected and is subject to misclassification and imputation errors.↗
▶Ep 33 · 5:02
epidemiologicalThis represents the first national study examining CDH incidence in Canada.↗
▶Ep 33 · 5:08
epidemiologicalSimilar to other populations, male fetal sex and older maternal age are associated with an increased incidence of CDH.↗
▶Ep 33 · 6:10
quotewe did try to evaluate what is in the water in Manitoba↗
▶Ep 33 · 6:20
epidemiologicalIn Manitoba, there is not an overall increased maternal age according to Statistics Canada trends.↗
▶Ep 33 · 6:35
opinionThe study group hypothesizes that there is an interplay between genetic, environmental, and sociodemographic influences affecting CDH incidence in Manitoba.↗
▶Ep 33 · 6:50
epidemiologicalA paper by Lou et al. found an increased incidence of gastroschisis in Manitoba, with northern regions of the province showing higher incidence.↗
▶Ep 33 · 7:08
opinionThe elevated gastroschisis incidence in northern Manitoba is thought to be related to the communities that settle in northern regions, access to prenatal care, and prenatal exposures.↗
