I think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.
I think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.
I think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.
I think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.
I think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.
I think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 2 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 2 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 2 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 2 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 2 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 2 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 2 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 2 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 2 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 2 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 2 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 2 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 2 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 2 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 2 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 2 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 4 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 4 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 4 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 4 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 4 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 4 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 4 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 4 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 4 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 4 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 4 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 4 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 4 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 4 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 4 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 4 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 6 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 6 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 6 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 6 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 6 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 6 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 6 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 6 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 6 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 6 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 6 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 6 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 6 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 6 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 6 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 6 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 10 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 10 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 10 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 10 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 10 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 10 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 10 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 10 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 10 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 10 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 10 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 10 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 10 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 10 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 10 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 10 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 76 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 76 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 76 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 76 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 76 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 76 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 76 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 76 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 76 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 76 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 76 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 76 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 76 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 76 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 76 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 76 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 26 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 26 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 26 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 26 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 26 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 26 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 26 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 26 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 26 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 26 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 26 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 26 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 26 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 26 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 26 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 26 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 3 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 3 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 3 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 3 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 3 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 3 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 3 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 3 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 3 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 3 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 3 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 3 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 3 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 3 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 3 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 3 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 7 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 7 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 7 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 7 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 7 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 7 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 7 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 7 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 7 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 7 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 7 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 7 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 7 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 7 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 7 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 7 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 14 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 14 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 14 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 14 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 14 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 14 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 14 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 14 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 14 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 14 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 14 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 14 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 14 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 14 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 14 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 14 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 35 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 35 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 35 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 35 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 35 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 35 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 35 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 35 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 35 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 35 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 35 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 35 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 35 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 35 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 35 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 35 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
Biliary Atresia, Appendicitis, Intestinal Failure, and Anesthetic...
▶Ep 4 · 31:31
host_summaryA PIFCON multi-center cohort study of 272 children with intestinal failure (median follow-up 33 months) found enteral autonomy was achieved in 43%, 13% remained PN-dependent, and 43% died or underwent transplant.↗
▶Ep 4 · 32:58
host_summaryNecrotizing enterocolitis as the underlying diagnosis, care at an intestinal rehab facility without a transplant center, and presence of an ileocecal valve were all statistically significantly associated with higher rates of enteral autonomy.↗
▶Ep 4 · 33:19
host_summaryResidual small bowel length was also a statistically significant predictor of enteral autonomy, though less impressive than the other three variables.↗
▶Ep 4 · 33:55
quoteTo me, one of the interesting parts is this protective effect of necrotizing enterocolitis, which in some ways goes against some of our understanding of that inflammatory illness, and it really shows us how much we have to learn.↗
▶Ep 4 · 33:55
opinionThe protective effect of necrotizing enterocolitis on enteral autonomy is surprising and goes against understanding of that inflammatory illness, showing how much remains to be learned.↗
▶Ep 4 · 34:46
host_summaryA companion paper in the same journal (Journal of Pediatrics, July 2015) found necrotizing enterocolitis was a poor predictor of growth outcome in infants with short bowel syndrome.↗
▶Ep 4 · 36:11
quoteI think what this paper really changes is the importance of children with intestinal failure and what we call short gut syndrome to really have the opportunity to be managed in one of these multidisciplinary intestinal rehab programs, because the combination of eliminating collapses and and cholestasis prevention is really going to has changed how we understand enteral autonomy and intestinal failure.↗
▶Ep 4 · 36:11
opinionThe PIFCON study underscores the importance of managing children with intestinal failure in multidisciplinary intestinal rehab programs, where catheter-associated bloodstream infection elimination and cholestasis prevention have changed outcomes.↗
▶Ep 4 · 38:09
host_summaryAnimal studies show that commonly used anesthetics and sedatives (propofol, etomidate, sevoflurane, isoflurane, ketamine) that increase GABA receptor activity or block glutamate receptors produce neurotoxic effects in laboratory animals from nematodes to nonhuman primates.↗
▶Ep 4 · 38:43
host_summaryObservational studies in children undergoing early anesthesia offer conflicting results and are confounded by multiple factors, but suggest some children may have deficits—association, not causation.↗
▶Ep 4 · 39:11
host_summarySmartTots June 2014 statement concluded that animal data is sufficiently convincing to warrant large-scale clinical studies and recommended avoiding anesthesia in children under 3 unless urgent or potentially harmful if not attended to.↗
▶Ep 4 · 40:53
opinionDr. Lipskar has not yet delayed an inguinal hernia repair for anesthetic concerns.↗
▶Ep 4 · 41:09
clinicalAt Cohen Children's Medical Center, circumcisions outside the neonatal period are done with general plus regional anesthesia.↗
▶Ep 4 · 41:31
quoteI find a lot of the correlations within this debate to the what happened with the CAT scan radiation risk debate, and I'm hesitant. To make too many changes without solid data as we completely changed how we work up appendicitis based on unclear data of cancer risks from radiation.↗
▶Ep 4 · 41:31
opinionRegional anesthesia and agents like precedex may help decrease the amount of potentially neurotoxic general anesthesia; almost every laparoscopic, thoracoscopic, or open operation has a regional block option.↗
▶Ep 4 · 43:17
clinicalA survey of ~150 parents in a primary care pediatrics office found the vast majority did not know anesthetic neurotoxicity was a major issue (Dr. Lipskar's unpublished study, to be presented at AAP).↗
