Collection
Pediatric Liver Transplantation
Educational content from recorded physician discussions — not medical advice. Always talk to your child's care team about your child's situation.
Content of this collection
Living Donor Transplantation1 item
Living Partial Liver Donation: A Life Saving Gift
Read →
Living Partial Liver Donation: A Life Saving Gift - Research Horizons Research Horizons Home Findings Features Announcements Learning Newsletter Subscribe Subspecialty News All Categories Announcements Features Findings Learning & Networkin
article · Oct 2026
Machine Perfusion and Graft Optimization1 item
Machine Perfusion and Mitigating Risk Factors for Delayed Graft Function in Pediatric Kidney Transplant Recipients.
Read →
Kidney transplantation confers prolonged and improved quality of life versus dialysis for patients with end-stage kidney disease (ESKD). Delayed graft function (DGF) increases the risk of allograft rejection and decreases allograft survival
article · Oct 2026
Anatomic and Technical Considerations2 items
Pediatric Liver Transplant: Anatomic, Imaging, and Surgical Considerations-A Report of the Pediatric LI-RADS Working Group, From the AJR Special Series on Critical Anatomy
Read →
Liver transplant is the definitive treatment of children with end-stage liver disease, select metabolic disorders, and unresectable hepatic malignancies. Radiologists play a central role in the multidisciplinary transplant team, contributin
article · Oct 2026
Pediatric Living Donor Liver Transplantation Outcomes-Is it Time for Outcome Optimization of Technical Aspects of Transplantation Using Learning Networks?
Read →
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2022
article · Oct 2026
Vascular Complications1 item
Hepatic Artery Pseudoaneurysm After Liver Transplantation
Read →
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016
article · Oct 2026
Ultra-Low Weight Recipients1 item
Ultra-Low Weight < 5 Versus 5-9.9-kg Pediatric Liver Transplant Recipients: Characteristics and Intraoperative Vasopressor Comparisons
Read →
Background: Survival in pediatric liver transplantation (PLT) has significantly improved in infants under 1 year, but < 10 kg and < 6 months continue to have poor outcomes with a paucity of information on ultra-low weight (ULW) infants (< 5
article · Oct 2026
Immunosuppression Strategies1 item
Anti-thymocyte globulin induction with delayed introduction of tacrolimus preserves renal function in pediatric liver transplant recipients
Read →
Background: Tacrolimus (TAC)-mediated renal disease occurs in up to 70% of pediatric liver transplant (LT) recipients. The safety and efficacy of renal-sparing immunosuppression using anti-thymocyte globulin (ATG) induction and delayed TAC
article · Oct 2026
Infectious Complications1 item
Impact of Hepatoblastoma on Infectious Complications Following Pediatric Liver Transplantation
Read →
Liver transplantation is the standard therapy for end‐stage liver disease in pediatric patients with biliary atresia (BA), congenital and metabolic conditions, and for an unresectable malignant tumor like hepatoblastoma (HB). BA is the lead
article · Oct 2026
Primary Non-Function and Re-transplantation1 item
Children undergoing early liver re-transplantation for primary non-function have improved survival
Read →
Background: Primary non-function (PNF) in the early post-LT period in children leads to prolonged hospitalization, high graft loss, and significant mortality. However, there is a paucity of data available on the natural history of children
article · Oct 2026
Post-Traumatic Liver Transplantation1 item
Pediatric liver transplant after traumatic liver injury: An analysis of the multicenter Scientific Registry of Transplant Recipients data set.
Read →
Liver injury is common in children with blunt or penetrating injury. In rare cases with devastating biliary or vascular injury, or posttraumatic acute hepatic failure, liver transplantation may be warranted. Outcomes of liver transplant aft
article · Oct 2026
Combined Heart-Liver Transplantation1 item
Outcomes of Fontan patients undergoing combined heart-liver transplantation in pediatric hospitals across the United States
Read →
With increasing numbers of patients surviving Fontan palliation, there is a rise in Fontan-associated liver disease and transplantation strategies inclusive of combined heart-liver transplantation (CHLT). Therefore, we reviewed a combined d
article · Oct 2026
Metabolic Syndrome Considerations1 item
Metabolic syndrome in liver transplantation: A preoperative and postoperative concern
Read →
Background: Metabolic syndrome is increasing among patients undergoing liver transplantation. Nonalcoholic steatohepatitis is a manifestation of metabolic syndrome and is an increasingly common cause of end-stage liver disease necessitating
article · Oct 2026
Pediatric Organ Donation and Transplantation: Across the Care Continuum
Read →
This policy statement aims to enhance comfort and increase knowledge of pediatric organ donation and transplantation to the general pediatric community, specifically focusing on the pediatric health care professional and the medical home. T
article · Oct 2026
By two weeks of age, if the baby still has jaundice, the pediatrician needs to fractionate the bilirubin; if the direct or conjugated fraction is elevated, think about pathologic jaundice — Jorge Bezerra, Biliary Atresia - Clinical Practice Updates · 4:16
HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer
Read →
Background & Aims: Epigenetic regulation of gene expression plays a critical role in the development of liver cancer; however, the molecular mechanisms of epigenetic-driven liver cancers are not well understood. The aims of this study were
article · Oct 2026
Myoepithelioma of the gland of the third eyelid in a dog
Read →
A 12-year-old female miniature dachshund was presented with a tan-white, firm mass (4 × 3 × 2 cm) occupying the left medial canthus. The mass compressed and displaced the left eye dorsally, and it was surgically removed. Microscopically, th
article · Oct 2026
Patient and Family Resources
Read →
Patient and Family Resources | Cincinnati Children's Schedule an Appointment Directions International Billing Sign in to MyChart Ways to Help Donate Now Navigation Patients and Families Patients and Family Home Schedule an Appointment Servi
article · Oct 2026
Resources for Healthcare Professionals
Read →
Resources for Healthcare Professionals Schedule an Appointment Directions International Billing Sign in to MyChart Ways to Help Donate Now Navigation Patients and Families Patients and Family Home Schedule an Appointment Services and Specia
article · Oct 2026
Researchers, Cincinnati Children's Hospital Medical Center
Read →
We believe in science and compassion. Learn how our scientists conduct breakthrough research to improve the lives of children every day.
article · Oct 2026
Support Services | Cincinnati Children's Research Foundation
Read →
Support services help design grant proposals, manage data, comply with regulations, protect intellectual property and assist with commercialization. Read more.
article · Oct 2026
Digestive Health Center (DHC)
Read →
The Digestive Health Center conducts digestive disease research and makes discoveries related to pediatric digestive conditions. Learn more about our work.
article · Oct 2026
Research
Read →
General and thoracic surgery researchers study new therapies to treat fetal, congenital and pediatric conditions as early as possible.
article · Oct 2026
Newsroom
Read →
Cincinnati Children’s is dedicated to keeping families, healthcare professionals, and the news media informed with the latest updates, discoveries, and institutional milestones.
article · Oct 2026
Pdf Non Discrimination Statement.Pdf
Read →
%PDF-1.4 %���� 4 0 obj > endobj xref 4 104 0000000016 00000 n 0000002731 00000 n 0000002867 00000 n 0000002975 00000 n 0000004106 00000 n 0000004245 00000 n 0000004382 00000 n 0000005347 00000 n 0000006805 00000 n 0000006942 00000 n 0000007
article · Oct 2026
Choledochal Cyst Surgery: Roux-en-Y Hepaticojejunostomy Technique Explained w/ Dr. Alexander Bondoc
Watch →
This video with Dr. Alexander Bondoc details one surgeon's preferred technique for performing a Roux-en-Y hepaticojejunostomy to treat choledochal cysts. It outlines key surgical steps, including the measurement of the Roux limb distal to t
video0:31 · Oct 2026
Biliary Atresia: Diagnosis and Lifelong Follow-up for Jaundiced Children w/ Dr. Alexander Bondoc
Watch →
This video addresses the critical considerations for a jaundiced child presenting with a right upper quadrant (RUQ) mass, emphasizing the importance of ruling out the cystic biliary atresia variant in neonates and newborns. Dr. Alexander Bo
video0:37 · Oct 2026
Hepatoblastoma & Liver Transplant: Criteria for Transplantability in Pediatric Patients
Watch →
Dr. Alexander Bondoc, a Pediatric Surgeon at Cincinnati Children's, explains the criteria for a hepatoblastoma patient to be considered transplantable. He highlights that children with hepatoblastoma automatically receive status 1B categori
video0:34 · Oct 2026
Biliary Atresia - Clinical Practice Updates
Watch →
This clip from the 2020 Pediatric Surgery Update Course features Alexander Bondoc, MD, presenting multiple cases and research conclusions from Atsuyuki Yamataka, MD; Greg Tiao, MD; Jorge Bezerra, MD; and Mark Davenport, MD, to our selected
video · Sep 2020
Biliary dyskinesia: diagnosis and management in pediatric patients
Watch →
http://www.cincinnatichildrens.org
Alexander Bondoc, MD, Pediatric Surgeon: "Hi, I’m Dr. Alex Bondoc, one of the general and transplant surgeons at Cincinnati Children’s, and today I’m here to talk to you about Biliary Dyskinesia. Biliary
video2:15 · Oct 2026
Choledochal Cyst Podcast
Listen →
In this podcast, Dr. Alex Bondoc and Dr. Rae Hanke discuss the intricacies of choledochal cysts. Contributing editor: Dr. Rod Gerardo.Choledochal Cyst- Definition: Congenital cystic dilation of the biliary tree- Epidemiology: We
podcast22:07 · Dec 2020
Summaries and takeaways+ Show
Summary of this collection+ Show
Key points+ Show
Featured picks for families are being prepared — the summaries above are written for you.
Takeaways+ Show
The doctors in this collection+ Show
All expert statements+ Show
Expert statements from the recordings in this collection.
Biliary Atresia - Clinical Practice Updates
In the US and Europe, alpha-1 antitrypsin deficiency is the most common cause of neonatal cholestasis in the differential diagnosis
epidemiologicalJorge Bezerra3:22 ↗
By two weeks of age, if the baby still has jaundice, the pediatrician needs to fractionate the bilirubin; if the direct or conjugated fraction is elevated, think about pathologic jaundice
guidelineJorge Bezerra4:16 ↗
The Taiwanese published in the Journal of Pediatrics in 2006 that they send all their kids home with stool color cards
clinicalAlex Bondoc6:13 ↗
MMP7 was identified as a serum marker of epithelial injury in biliary atresia through large-scale proteomic analysis of 30 children with biliary atresia in 2017
clinicalAlex Bondoc9:59 ↗
MMP7 using a cutoff value of 52-53 nanograms per ml demonstrated a sensitivity of diagnosing biliary atresia of about 98% with a specificity of about 95% in 135 consecutive infants in China
clinicalAlex Bondoc10:40 ↗
The MMP7 assay is run every other day and is a six-hour assay
clinicalJorge Bezerra12:51 ↗
MMP7 has the potential to eliminate a lot of other testing and eliminate things like a liver biopsy if confidence grows in its impact
opinionAlex Bondoc13:10 ↗
Cutoff values for MMP7 changed depending on reports from Asia, with much lower cutoff levels reported from Taiwan and China
clinicalJorge Bezerra12:20 ↗
A combination of blood tests and laparoscopy can diagnose biliary atresia promptly and accurately
clinicalAlex Bondoc14:44 ↗
Nearly all patients with biliary atresia have a hard liver, whereas hepatitis and Alagille syndrome patients have livers that are not as hard
clinicalYamataka17:57 ↗
Bile duct proliferation and portal edema may not appear on very early liver biopsies and may delay diagnosis by up to 30 days
clinicalAlex Bondoc17:09 ↗
In Yamataka's series, 16 cases were not typical biliary atresia on laparoscopy, and all 16 were confirmed not to be biliary atresia, including 8 cases of Alagille syndrome
clinicalYamataka19:13 ↗
If you do a Kasai operation on Alagille patients, you just shorten that patient's natural liver life and convert those patients to needing transplant at a much earlier age
clinical18:24 ↗
Infants coming to surgery for other matters who later turned out to have biliary atresia in the first week of life all had normal livers, so you can't diagnose early biliary atresia on liver biopsy
clinicalMark Davenport22:18 ↗
Liver histology looking at inflammation and fibrosis has not shown great discrimination for prognosis in babies coming to surgery before 100 days
clinicalMark Davenport23:08 ↗
Liver biopsy has additional value to quantify inflammation and use that information to personalize treatment
opinionJorge Bezerra24:04 ↗
The key differential for a prenatally detected cyst is between cystic biliary atresia and a choledochal cyst
clinicalMark Davenport24:57 ↗
If the baby is not jaundiced and not raising conjugated bilirubin, then it's not cystic biliary atresia and you can wait to do the laparotomy
clinicalMark Davenport25:51 ↗
Cystic biliary atresia patients get to surgery earlier, potentially because of prenatal diagnosis and heightened level of suspicion
clinicalAlex Bondoc26:20 ↗
Choledochal Cyst Podcast
Choledochal cyst is a congenital cystic dilation of the biliary tree.
clinicalAlex Bondoc0:29 ↗
Incidence of choledochal cysts in the Western world is about 1 in 100,000.
epidemiologicalAlex Bondoc0:36 ↗
In Eastern Asia, choledochal cyst incidence is 1 in 13,000.
epidemiologicalAlex Bondoc0:36 ↗
Choledochal cysts are three to four times more likely in females than in males.
epidemiologicalAlex Bondoc0:36 ↗
There is no genetic predisposition to choledochal cysts, but some genes including PKD1 have been identified in limited studies for type 5 choledochal cysts.
clinicalAlex Bondoc0:36 ↗
The most common classification system for choledochal cysts was developed by a surgeon named Tadani in Japan and includes five types.
clinicalAlex Bondoc1:10 ↗
For types 1 and 4 choledochal cysts, the etiology is likely embryologic, relating to pancreaticobiliary duct junction (pancreaticobiliary malunion), which creates a long common channel of the pancreaticobiliary duct.
clinicalAlex Bondoc1:10 ↗
Reflux of pancreatic enzymes from the head of the pancreas back into the biliary tree causes inflammation, degeneration, and epithelial changes in types 1 and 4 choledochal cysts.
clinicalAlex Bondoc1:10 ↗
In type 5 choledochal cysts, genetic mutation might predispose to more diffuse dilation of both the intra- and extrahepatic biliary trees.
clinicalAlex Bondoc1:10 ↗
Type 1 choledochal cyst is a dilation of the extrahepatic common bile duct only, which can be fusiform or saccular.
clinicalAlex Bondoc2:05 ↗
Type 2 choledochal cyst is a small diverticulum off of the common bile duct.
clinicalAlex Bondoc2:05 ↗
What's new+ Show