What is the role of neutropenia in pediatric cancer patients with pneumatosis intestinalis?
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In brief
In brief
This retrospective study of 68 pediatric cancer patients with pneumatosis intestinalis found that vasopressor requirement at diagnosis predicts need for surgical intervention, while neutropenia paradoxically correlates with lower recurrence rates. The findings help risk-stratify this serious gastrointestinal complication in immunocompromised children.
Written by the GCMD Library team from the article.
Abstract
Background
We aimed to identify prognostic indicators in pneumatosis intestinalis (PI) in a pediatric oncology population. We hypothesized that neutropenia would be an independent risk factor for adverse outcomes, including the need for abdominal operation to treat PI and for the development of recurrent PI.
Methods
We performed a retrospective review of all patients treated for PI between 2009 and 2019 with a diagnosis of cancer or history of bone marrow transplant (BMT).
Results
Sixty-eight children were treated for their first episode of PI; 15 (22%) were not neutropenic at presentation; eight underwent urgent abdominal operation (12%). Patients with neutropenia were more likely to receive TPN, had a longer course of NPO, and received a longer course of antibiotics. Neutropenia at presentation was associated with a decreased risk of PI recurrence (40% vs 13%, p = 0.03). Children who required an abdominal operation were more likely to require vasopressors at diagnosis (50% vs 10%, p = 0.013).
Conclusions
Among pediatric cancer patients, need for vasopressors at the time of PI is a marker of severe PI, with increased likelihood of requiring operative intervention. The presence of neutropenia is associated with lower rates of PI recurrence.
Level of evidence
Level III.