Use of thromboelastography in children on extracorporeal membrane oxygenation
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Read the article on jpedsurg.org ↗Article · Feb 2022 · 1 min read
In brief
In brief
Retrospective study of 296 pediatric ECMO patients examining correlation between thromboelastography (TEG) parameters and standard coagulation measures in heparinized patients. Analysis of 2502 matched laboratory samples demonstrates TEG's potential as a point-of-care tool for guiding anticoagulation management in this high-risk population.
Written by the GCMD Library team from the article.
Introduction
: Extracorporeal membrane oxygenation (ECMO) profoundly impacts inflammatory and coagulation pathways, and strict monitoring is essential to guide therapeutic anticoagulation. Thromboelastography (TEG) offers a global evaluation of whole blood hemostatic system components and may be a valuable measurement of hemostatic function in these patients. There is a paucity of data correlating TEG parameters with standard measures of coagulation in heparinized pediatric patients.
Methods
: Children on ECMO during a 10-year period were retrospectively reviewed. Standard measures of coagulation were matched to TEGs drawn within 30 minutes of each other.
Results
: Out of 296 unique patients with 331 ECMO runs, 74.3% (n=246) had at least one set of matched laboratory samples for a total of 2502 matched samples. The aPTT correlated with R-time (p