Update on pediatric testicular germ cell tumors
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Jun 2022 · 1 min read
In brief
In brief
This review synthesizes current evidence-based approaches to pediatric testicular germ cell tumors, covering diagnostic evaluation, surgical techniques, medical management, and risk stratification based on recent cooperative group trials. The authors emphasize the importance of international collaboration and clinical trial enrollment to advance knowledge and improve outcomes for these rare tumors.
Written by the GCMD Library team from the article.
Background: Testicular germ cell tumors are uncommon tumors that are encountered by pediatric surgeons and urologists and require a knowledge of appropriate contemporary evaluation and surgical and medical management.
Method: A review of the recommended diagnostic evaluation and current surgical and medical management of children and adolescents with testicular germ cell tumors based upon recently completed clinical trials was performed and summarized in this article.
Results: In this summary of childhood and adolescent testicular germ cell tumors, we review the initial clinical evaluation, surgical and medical management, risk stratification, results from recent prospective cooperative group studies, and clinical outcomes. A summary of recently completed clinical trials by pediatric oncology cooperative groups is provided, and best surgical practices are discussed.
Conclusions: Testicular germ cell tumors in children are rare tumors. International collaborations, data-sharing, and enrollment of patients at all stages and risk classifications into active clinical trials will enhance our knowledge of these rare tumors and most importantly improve outcomes of patients with testicular germ cell tumors.
Level of evidence: This is a review article of previously published and referenced level 1 and 2 studies, but also includes expert opinion level 5, represented by the American Pediatric Surgical Association Cancer Committee.
DOI: 10.1016/j.jpedsurg.2021.04.001