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Read the article on jpedsurg.org ↗Article · Oct 2018 · 1 min read
In brief
In brief
Comprehensive review of neuroblastoma, the most common extracranial solid tumor in children, covering current advances in staging, risk stratification, and treatment approaches. Discusses the variable clinical course from spontaneous regression in infants to aggressive disease in older children, driven by diverse tumor biology and genetics.
Written by the GCMD Library team from the article.
Neuroblastoma is an embryonic cancer arising from neural crest stem cells. This cancer is the most common malignancy in infants and the most common extracranial solid tumor in children. The clinical course may be highly variable with the possibility of spontaneous regression in the youngest patients and increased risk of aggressive disease in older children. Clinical heterogeneity is a consequence of the diverse biologic characteristics that determine patient risk and survival. This review will focus on current progress in neuroblastoma staging, risk stratification, and treatment strategies based on advancing knowledge in tumor biology and genetic characterization.
Type of study
Review article.
Level of evidence
Level II.