Ultrasound Elastography as a Non-Invasive Method to Monitor Liver Disease in Children with Short Bowel Syndrome: Updated Results
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Read the article on jpedsurg.org ↗Article · Mar 2019 · 1 min read
In brief
In brief
Prospective study of 31 pediatric short bowel syndrome patients evaluating ARFI ultrasound elastography as a non-invasive alternative to liver biopsy. Shear wave speed measurements showed significant correlation with fibrosis stage, suggesting elastography may enable serial monitoring of intestinal failure-associated liver disease without repeated biopsies.
Written by the GCMD Library team from the article.
Purpose
The purpose of the study was to determine the accuracy of acoustic radiation force impulse (ARFI) ultrasound elastography in assessing the degree of liver disease in children with short bowel syndrome (SBS).
Methods
A prospective observational cohort study of patients with SBS who underwent a liver biopsy and ARFI elastography was performed. Mean shear wave speed (SWS) and stage of fibrosis was evaluated using t-tests. Receiver operating characteristic curves (ROC) were generated and the area under the curves (AUC) estimated in order to assess the accuracy of SWS measurements to discriminate between stages of fibrosis.
Results
Thirty-seven paired elastography and biopsy samples from 31 patients were included. The median age was 0.6 years, and 61% were male. There was a significant positive correlation between stage of fibrosis and mean SWS (β=0.16 m/s increase per stage, p=