Translational research in Hirschprung’s disease at the National Children’s Research Centre in Dublin
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In brief
In brief
Comprehensive review of 144 peer-reviewed publications from the National Children's Research Centre in Dublin documenting translational research advances in Hirschsprung's disease. The NCRC's work spans animal models and human studies of congenital aganglionosis, establishing the center as a leading international authority on HD and related enteric nervous system disorders.
Written by the GCMD Library team from the article.
Abstract
Hirschsprung’s disease (HD) is a congenital condition characterised by aganglionosis in the distal bowel. Over the years, at the National Children’s Research Centre (NCRC), HD has been one of the most prominent and successful research areas for Prof. Prem Puri’s research team. Research fellows from around the world came to the NCRC to work on both animal and human studies of HD and, cumulatively, made important discoveries in this field, publishing a total of 144 HD articles in peer-reviewed journals. Through their published work, the NCRC has been recognised as the leading international centre for the investigation of HD and its allied disorders. In this review, I will summarise the main findings from this work.