Tracheal cartilage growth promotion by intra-tracheal administration of basic FGF
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Read the article on link.springer.com ↗Article · Jan 2020 · 1 min read
In brief
In brief
Experimental study demonstrates that intra-tracheal administration of basic FGF in mice significantly increases tracheal cartilage growth and luminal diameter in a dose-dependent manner. Effects persisted through 16 weeks, suggesting potential therapeutic application for congenital or acquired tracheal stenosis in pediatric patients.
Written by the GCMD Library team from the article.
Abstract
Purpose
This study aimed to investigate whether intra-tracheal administration of basic fibroblast growth factor (b-FGF) promotes the growth of tracheal cartilage.
Methods
Trachea of 4-week old mice were intubated and 2.5 μg b-FGF administered (Group 4) for periods from 1 to 5 days. Cervical tracheal outer diameter and tracheal ring length were compared in Group 1 (no intervention), Group 2 (tracheal intubation), Group 3 (intra-tracheal administration of distilled water) and Group 4, at 8 weeks of age. Outer diameter and tracheal ring length in Group 4 were also compared with that in Group 1 at 12 and 16 weeks of age.
Results
At 8 weeks of age, tracheal ring length with b-FGF administration for more than 4 days in Group 4 was significantly increased over that following 1-day administration. At 8 weeks of age, mean outer diameter and the mean tracheal ring length in Group 4 were significantly greater than in the other groups. Mean outer diameter and mean tracheal ring length were significantly greater in Group 4 than in Group 1 at 12 and 16 weeks of age.
Conclusion
This study has shown that intra-tracheal administration of b-FGF enlarges the tracheal lumen.