Tracheal Allotransplantation to Deliver Growing Airway Implants for Infants and Children

jpedsurg.org

The first successful organ transplantation was performed by Dr. Joseph Murray at The Peter Bent Brigham Hospital in 1954 [1]. After the transplantation of a kidney between two identical twin brothers, the recipient survived eight years without immunosuppression. By the early 60s, allotransplantation involving non-perfect matchesfinally proved successful by leveraging pharmacologic immunosuppression with cyclophosphamide and methotrexate [1]. In the following decades, more organs began to be successfully transplanted, including the heart in 1967, the heart/lung block in 1981 and the lungs in 1983 [1].

jpedsurg.org shows its articles on its own site.

Read the article on jpedsurg.org ↗

Article · Nov 2024 · 1 min read

In brief

This article explores tracheal allotransplantation as a solution for delivering growing airway implants in pediatric patients. It contextualizes this emerging procedure within the historical evolution of organ transplantation and immunosuppression strategies, highlighting its potential for children with congenital or acquired airway defects.

First successful organ transplant (kidney) occurred in 1954 between identical twins, with 8-year survival without immunosuppression.
Pharmacologic immunosuppression with cyclophosphamide and methotrexate enabled successful allotransplantation in non-identical matches by early 1960s.
Major organ transplant milestones: heart (1967), heart-lung block (1981), and isolated lungs (1983).
Tracheal allotransplantation represents frontier in pediatric airway reconstruction, building on decades of solid organ transplant advances.

Written by the GCMD Library team from the article.

Read it at the source ↗