The undescended testis in children and adolescents. Part 1: pathophysiology, classification, and fertility- and cancer-related controversies
pubmed.ncbi.nlm.nih.gov shows its articles on its own site.
Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Aug 2022 · 1 min read
In brief
In brief
This comprehensive review examines undescended testis (UDT), affecting 3% of male infants, focusing on pathophysiology and long-term risks of infertility and testicular cancer. Part 1 challenges traditional management myths and emphasizes the importance of understanding germ cell development alterations beyond surgical intervention alone.
Written by the GCMD Library team from the article.
Undescended testis (UDT) is defined as failure of a testis to descend into the scrotum. It is one of the most common reasons for consultation in pediatric surgery and urology with an incidence of 3% in live-born male infants. Decades ago, classical studies established that the failure of a testis to descend alters the development of its germ cells increasing the risk of infertility and testicular cancer in adulthood. More recent publications have rebutted some of the myths and raised controversies regarding the management of these patients, which, far from being limited to surgical treatment, should include pathophysiological and prognostic aspects for a comprehensive approach to the condition. Therefore, here we present an updated review divided into two parts: the first assessing the pathophysiological aspects and risks of these patients focused on fertility and cancer, and the second addressing the different treatment options for UDT.
DOI: