The protective effects of fecal microbiota transplantation in an experimental model of necrotizing enterocolitis
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In brief
In brief
Experimental study demonstrates fecal microbiota transplantation reduces inflammatory markers, oxidative damage, and intestinal injury in a rat model of necrotizing enterocolitis. Both prophylactic and therapeutic FMT administration showed protective effects, suggesting potential therapeutic applications for this devastating neonatal condition.
Written by the GCMD Library team from the article.
Background
Necrotizing enterocolitis (NEC) is a serious disease that affects premature neonates, causing high mortality. In the search for new options of treatment it was investigated whether fecal microbiota transplantation (FMT) decreased the inflammatory response during NEC development in experimental model.
Methods
Wistar rats were used and divided as follows: naïve, control (NEC induction), FMT-before (transplantation of microbiota before insult) and FMT-after (microbiota transplantation after insult). The microbiota transplantation was performed by administering a feces solution obtained from an adult donor rat. The induction of enterocolitis involves feeding by artificial formula, hypothermia, hypoxia and endotoxin administration. MPO activity, TNF-α, IL-1β and IL-6 levels, oxidative and nitrosative damage and the grade of intestinal mucosa lesion were analyzed.
Results
The control group had a significant increase of inflammatory and oxidative parameters when compared to naive animals. Both FMT-before and after decreased all inflammatory and oxidative damage parameters when compared to control group. This was also true to the intestinal mucosa damage.
Conclusion
FMT administered just before or after NEC induction improved gut and systemic inflammation, and gut oxidative damage and intestinal injury.