The Long Term Effects of Intrascrotal Low Dose and High Dose N-Acetylcysteine on Testis Damage in Rat Model of Testicular Torsion
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In brief
In brief
This rat model study demonstrates that high-dose intrascrotal N-acetylcysteine (100 mg/kg) administered during detorsion significantly preserves testicular volume, height, and Sertoli cell counts compared to untreated torsion-detorsion. The findings suggest a potential protective role for local NAC therapy in mitigating ischemia-reperfusion injury during testicular torsion management.
Written by the GCMD Library team from the article.
Background/Purpose
During testicular torsion, the testes face oxidative damage owing to ischemia/reperfusion. We studied the long term effects of the intrascrotal administration of N-acetylcysteine (NAC) during detorsion procedure in a rat model of testicular torsion.
Methods
Twenty-eight rats were divided into 4 groups: (1) Control group: No procedure was done (2): Torsion–detorsion group: Testis torsion applied for 3 h (3): Low Dose Group: After testis torsion–detorsion (for 3 h) 10 mg/kg NAC was given into tunica vaginalis (4): High Dose Group: After testis torsion–detorsion (for 3 h) 100 mg/kg NAC was given into tunica vaginalis. We measured dimensions of the testes and examined pathological findings and Johnsen and Cosantino Scores.
Results
For testes height and volume, high dose NAC group had better results than the torsion–detorsion group (p = 0.019, p = 0.049). Testes weight showed no difference (p = 0.204). Sertoli cell number per tubule in the high dose NAC group was statistically different than the torsion–detorsion group (p = 0.017).
Conclusions
When NAC was given intrascrotally at a dose of 100 mg/kg, it decreased the loss of testis volume and height, and Sertoli cell number per tubule was similar to the control group. These results suggest that the higher dose intrascrotal NAC administered during detorsion may have a protective effect.