THE IMPACT OF LOW RECIPIENT WEIGHT [≤ 7Kg] ON LONG-TERM OUTCOMES IN 1078 PEDIATRIC LIVING DONOR LIVER TRANSPLANTATIONS
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In brief
In brief
This retrospective study of 1,078 pediatric living donor liver transplants compared outcomes in infants ≤7kg versus larger recipients. Despite higher malnutrition, transfusion requirements, and portal vein complications in the low-weight cohort, long-term patient and graft survival rates were equivalent between groups.
Written by the GCMD Library team from the article.
Background
infants who require liver transplantation represent a treatment challenge because chronic liver disease at this early age affects the child's growth and development during a critical phase. The aim is to compare demographics, operative data, and long-term outcomes according to recipient weight at the time of LDLT.
Methods
This retrospective study included primary LDLT analyzed in 2 groups: BW ≤ 7 kg (n=322) and BW > 7 kg (n=756). A historical comparison between periods was also investigated.
Results
BW ≤ 7 kg had significantly lower height/age and weight/age z-scores, with median PELD score of 19. Transfusion rates were higher in the BW ≤ 7 kg group (30.9 ml/kg versus 15.5 ml/kg, P < 0.001). Higher frequencies of PV complications were seen in the BW ≤ 7 kg cohort. HAT and retransplantation rates were similar. Those with BW ≤ 7 kg required longer ICU and hospital stays. Patient and graft survival were similar. Patient survival in BW≤ 7 kg was significantly better in the most recent period.
Conclusion
Malnutrition and advanced liver disease were more frequent in BW ≤ 7 kg. Despite increased rates of PVT and longer hospital stay, patient and graft long-term survival were similar between groups.