Article1 min read·Published Dec 2015Older

The human milk oligosaccharide 2'-fucosyllactose augments the adaptive response to extensive intestinal

Part of Intestinal Stem Cells & Regeneration 24 items

pubmed.ncbi.nlm.nih.gov

Michael Helmrath

Intestinal resection resulting in short bowel syndrome (SBS) carries a heavy burden of long-term morbidity, mortality, and cost of care, which can be attenuated with strategies that improve intestinal adaptation. SBS infants fed human milk, compared with formula, have more rapid intestinal adaptation. We tested the hypothesis that the major noncaloric human milk oligosaccharide 2'-fucosyllactose (2'-FL) contributes to the adaptive response after intestinal resection. Using a previously described murine model of intestinal adaptation, we demonstrated increased weight gain from 21 to 56 days (P < 0.001) and crypt depth at 56 days (P < 0.0095) with 2'-FL supplementation after ileocecal resection. Furthermore, 2'-FL increased small bowel luminal content microbial alpha diversity following resection (P < 0.005) and stimulated a bloom in organisms of the genus Parabacteroides (log2-fold = 4.1, P = 0.035). Finally, transcriptional analysis of the intestine revealed enriched ontologies and pathways related to antimicrobial peptides, metabolism, and energy processing. We conclude that 2'-FL supplementation following ileocecal resection increases weight gain, energy availability through microbial community modulation, and histological changes consistent with improved adaptation.

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Article · Dec 2015 · 1 min read

In brief

This study demonstrates that 2'-fucosyllactose, a major human milk oligosaccharide, enhances intestinal adaptation following ileocecal resection in a murine model of short bowel syndrome. Supplementation improved weight gain, increased microbial diversity with beneficial Parabacteroides expansion, and promoted histological changes consistent with enhanced adaptation through modulation of antimicrobial peptides and energy metabolism pathways.

Written by the GCMD Library team from the article.

Michael Helmrath

Statements in this article

Short bowel syndrome carries a heavy burden of long-term morbidity, mortality, and cost of care.
Established
Strategies that improve intestinal adaptation can attenuate the burden of short bowel syndrome.
Established
Infants with short bowel syndrome fed human milk have more rapid intestinal adaptation compared with formula.
Research
2'-fucosyllactose supplementation after ileocecal resection increased weight gain from 21 to 56 days (P < 0.001) in a murine model.
Research
2'-fucosyllactose supplementation increased crypt depth at 56 days (P < 0.0095) after ileocecal resection in a murine model.
Research
2'-fucosyllactose increased small bowel luminal content microbial alpha diversity following resection (P < 0.005).
Research
2'-fucosyllactose stimulated a bloom in organisms of the genus Parabacteroides (log2-fold = 4.1, P = 0.035) following resection.
Research
Transcriptional analysis of the intestine after 2'-fucosyllactose supplementation revealed enriched ontologies and pathways related to antimicrobial peptides, metabolism, and energy processing.
Research
2'-fucosyllactose supplementation following ileocecal resection increases weight gain, energy availability through microbial community modulation, and histological changes consistent with improved adaptation.
Research