The evolution of early liver biopsy findings in babies with jaundice may delay the diagnosis and treatment of biliary atresia
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Read the article on jpedsurg.org ↗Article · Mar 2020 · 1 min read
In brief
In brief
Early liver biopsy in jaundiced infants may show atypical histology that delays biliary atresia diagnosis and timely portoenterostomy. This retrospective study of 6 cases demonstrates that repeat biopsies can rapidly evolve to show characteristic features, highlighting the need for clinical vigilance when initial histology is inconclusive.
Written by the GCMD Library team from the article.
Background
The early diagnosis of biliary atresia (BA) is associated with a better outcome after portoenterostomy. However, very early liver biopsy findings may appear atypical for BA and delay diagnosis. Repeat biopsy histology may change rapidly to show more typical features.
Methods
Between 1997 and 2018, 6 babies with jaundice had more than one biopsy to establish diagnosis. Clinical and histologic data were collected. chi-Square was used for analysis (p