Survival in children with hepatoblastoma and pulmonary metastatic disease at diagnosis based on extent of metastases and need for surgical clearance

In brief

This study examines survival outcomes in children with hepatoblastoma presenting with lung metastases, evaluating how metastatic burden and chemotherapy response impact prognosis. The research demonstrates that long-term survival is achievable even with extensive pulmonary disease when surgical resection of metastases is performed.

• Pulmonary metastatic burden at diagnosis significantly impacts survival outcomes in pediatric hepatoblastoma patients.
• Chemotherapy response is a critical determinant of disease-free and overall survival in metastatic hepatoblastoma.
• Surgical metastasectomy can achieve long-term survival even in children with extensive pulmonary metastases.
• Complete surgical clearance of pulmonary metastases improves prognosis in hepatoblastoma with lung involvement.

Written by the GCMD Library team from the article.