Surgical outcomes and survival rates of colon cancer in children and young adults
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Apr 2021 · 1 min read
In brief
In brief
National Cancer Database analysis of 531,462 colon cancer patients reveals that those ≤25 years present with more advanced disease and require more extensive surgery than older patients, yet demonstrate superior stage-matched 5-year survival rates. Age itself was not an independent mortality risk factor.
Written by the GCMD Library team from the article.
Introduction: Colon cancer in children and young adults is rare. We sought to compare outcomes and survival between patients ≤and>25 years of age with colon cancer.
Methods: Using the National Cancer Database, patients with colon cancer between 2004 and 2016 were identified. We included patients with histological codes consistent with invasive colon adenocarcinoma and excluded those missing data about treatment. Post-surgical outcomes and survival were compared.
Results: Of 531,462 patients meeting criteria, 947 were ≤25 years. Patients ≤25 had more advanced disease (stage III:44.4%vs33.4%, stage IV:27.5%vs.15.3%) and higher rates of total colectomy (8.9%vs.2.7%) and proctocolectomy (5.0%vs.0.0%) than those >25 years. Stage for stage, 5-year survival was higher in patients ≤25 than those >25years. On multivariate regression, age was not associated with increased risk of mortality while male sex and uninsured status were.
Conclusions: Despite presenting with more advanced disease, patients ≤25 years with colon cancer had better survival than those >25 years.
DOI: 10.1016/j.amjsurg.2021.02.010