Self-compounded Doxycycline Sclerotherapy for the Treatment of Lymphatic Malformations in Low-Resource Settings
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Sep 2020 · 1 min read
In brief
In brief
This retrospective study from Rwanda demonstrates that self-compounded doxycycline sclerotherapy is an effective, low-cost alternative to surgery for pediatric lymphatic malformations in resource-limited settings. Eight of ten patients achieved at least 80% resolution with minimal complications, making this approach particularly valuable for LMICs where commercial sclerosing agents may be unavailable or prohibitively expensive.
Written by the GCMD Library team from the article.
Background: Congenital anomalies are one component of the overwhelming surgical disease burden in low- and middle-income countries (LMICs). Lymphatic malformations (LMs) are a common congenital deformity of the head and neck in which the utilization of sclerotherapy may avoid surgery and yield superior outcomes. To be useful in LMICs, sclerosing agents must be widely available, inexpensive, and effective.
Methods: A retrospective review of 10 pediatric patients with macrocystic or mixed LMs who were treated with self-compounded doxycycline sclerotherapy at Rwanda's Central University Teaching Hospital of Kigali was performed. Doxycycline oral tablets were crushed by hand, mixed with normal saline at a concentration of doxycycline 10 mg/mL, and injected directly into LMs of the head and neck.
Results: Ten pediatric patients underwent 21 sclerotherapy sessions with a mean of 2.1 sessions per patient (SD 1.3, range 1-5). Of the 8 patients that were seen in follow-up, all achieved at least 80% resolution, 6 of 8 achieved 100% resolution, and none required surgery. One patient developed an infection at the injection site which resolved with antibiotics.
Conclusions: Self-compounded doxycycline sclerotherapy is a safe, effective, and widely available treatment option for sclerotherapy of LMs in LMICs.
DOI: 10.1007/s00268-020-05667-z