StayCurrentMD · Sample size analysis
Article1 min read·Published Jul 2020Older

Sample size analysis

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Article · Jul 2020 · 1 min read

In brief

In brief

This journal club discussion examines sample size methodology for a randomized trial comparing lavage versus suction in laparoscopic appendectomies. The analysis focuses on Type II error calculation and statistical power, determining the sample size needed to detect a clinically meaningful difference between treatment groups.

Written by the GCMD Library team from the article.

Our journal club enjoyed Nataraja et al.'s randomized trial: lavage vs suction in laparoscopic appendicectomies [1]. Section 1.4.1 considered two distributions (means 4.4 and 5.5 days, sd 1.29), and asked how large, equal sized, samples needed to be such that the chance of getting a p-value  > 0.05 was about 20%:— this being the chance of making a Type II error, of wrongly accepting the null hypothesis when the parent populations differ. The Type II error is less well understood than the Type I error, represented by the p-value, being the chance of wrongly rejecting the null hypothesis when there is no difference between the parent populations.

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