Safety of delayed surgical repair of omphalocele–exstrophy–imperforate anus–spinal defects (OEIS) complex in infants with significant comorbidities
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In brief
In brief
Retrospective study of 10 OEIS complex patients demonstrates that delaying first-stage exstrophy repair (6-87 days) to optimize cardiopulmonary and neurologic stability is safe, with no urinary tract infections occurring pre-repair. All surgically repaired patients achieved discharge without parenteral nutrition or oxygen support.
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Abstract
Purpose
Management of infants with OEIS complex is challenging and not standardized. Expeditious surgery after birth has been recommended to limit soilage of the urinary tract and optimize intestinal function. However, clinical instability secondary to comorbidities is common in this population and early operation carries risk. We sought to define the risk/benefit profile of delaying repair.
Methods
All newborn patients with OEIS managed by our institution between Sep 2017 and Oct 2019 were reviewed. Comorbidities were evaluated, including cardiopulmonary pathologies and associated malformations.
Results
Ten patients with OEIS were managed. Patients underwent early (2 patients, repair at 0–2 days) or delayed (6 patients, repair at 6–87 days) first-stage exstrophy repair. Two patients died prior to repair (progressive respiratory failure, severe genetic anomalies). Repairs were delayed secondary to cardiac conditions, neurosurgical interventions, medical disease, and/or delayed transfer. Delayed repair patients had longer lengths of stay and use of parenteral nutrition. No patients experienced urinary tract infections prior to repair.
Conclusions
Delaying first-stage exstrophy repair to allow physiologic optimization is safe. All repaired patients were discharged home, without parenteral nutrition or supplemental oxygen.