ROUTINE BOTULINUM TOXIN INJECTION ONE MONTH AFTER A SWENSON PULL-THROUGH DOES NOT CHANGE THE INCIDENCE OF HIRSCHSPRUNG ASSOCIATED ENTEROCOLITIS
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Read the article on jpedsurg.org ↗Article · Dec 2021 · 1 min read
In brief
In brief
Retrospective study comparing Hirschsprung disease patients who received routine botulinum toxin injection one month after Swenson pull-through versus those who did not. Results indicate that prophylactic botulinum toxin does not reduce the incidence of Hirschsprung-associated enterocolitis (HAEC) in the postoperative period.
Written by the GCMD Library team from the article.
Purpose
: Patients with Hirschsprung disease (HD) are at risk of Hirschsprung associated enterocolitis (HAEC) following pull-through. The purpose of this study was to determine if routine Botulinum toxin (BT) injected one-month post pull-through decreases the incidence of HAEC.
Methods
: We reviewed patients who underwent a primary (not redo) pull-through operation for HD between April 2014 to December 2019. Over the most recent 18 months, BT was administered routinely one-month post-pull-through procedure, and these patients were compared to the prior group that did not receive routine BT. A HAEC episode was defined as one that required initiation of treatment for obstructive symptoms in the inpatient or outpatient setting with antibiotics and irrigations. Categorical variables were compared using the nonparametric chi-square test or Fisher's exact test. Continuous variables were compared using the two-tailed Student's t-test. P-value