Role of Urinary Biomarkers in the Postoperative Follow-up of Ureteropelvic Junction Obstruction: A Preliminary Report

jpedsurg.org

While the role of urinary biomarkers in differentiating non-obstructive dilatation (NOD) from ureteropelvic junction obstruction (UPJO) has been documented, there are limited reports on their utility in post-operative follow-up. This study aimed to document the values of urinary biomarkers: carbohydrate antigen (CA 19-9), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule (KIM-1) following pyeloplasty.

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Article · May 2025 · 1 min read

In brief

This study investigates urinary biomarkers (CA 19-9, NGAL, KIM-1) as tools for monitoring kidney function after pyeloplasty surgery for ureteropelvic junction obstruction. While biomarkers help distinguish obstructive from non-obstructive cases preoperatively, their postoperative utility remains underexplored, making this preliminary work valuable for pediatric urologists tracking surgical outcomes.

Urinary biomarkers (CA 19-9, NGAL, KIM-1) may have utility in monitoring post-pyeloplasty outcomes beyond their established role in diagnosing UPJO.
Limited evidence exists on biomarker trends after surgical correction of UPJO, representing a gap in postoperative surveillance strategies.
This preliminary study establishes baseline data for CA 19-9, NGAL, and KIM-1 levels following pyeloplasty for future validation studies.
Biomarker monitoring could potentially offer objective assessment of surgical success and early detection of persistent obstruction after pyeloplasty.

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