Role of Emerging Urinary Biomarkers in Predicting Progressive Deterioration of Kidney Function in Congenital Anomalies of Kidney and Urinary Tract: Trefoil Family Factor 3, Alpha Soluble Klotho and Urinary Microalbuminuria

jpedsurg.org

Chronic kidney disease is an irreversible fate of many CAKUT (Congenital Abnormalities of the Kidneys and Urinary Tract) patients. Biomarkers involved in the disease progression are raised early in the disease process and aid in identifying the individuals at risk of progressive renal function decline.

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Article · Oct 2024 · 1 min read

In brief

This article examines novel urinary biomarkers—trefoil family factor 3, alpha soluble klotho, and microalbuminuria—for early detection of progressive kidney function decline in patients with congenital kidney and urinary tract anomalies. These markers may enable clinicians to identify at-risk CAKUT patients before irreversible chronic kidney disease develops.

CAKUT patients face irreversible progression to chronic kidney disease, requiring early risk stratification.
Trefoil Family Factor 3, alpha soluble Klotho, and microalbuminuria are emerging urinary biomarkers for CAKUT progression.
These biomarkers rise early in disease process, enabling identification of at-risk patients before significant function loss.
Early biomarker detection allows targeted intervention to slow progressive renal decline in CAKUT populations.

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