Risk factors for enterocolitis in patients with Hirschsprung disease: A retrospective observational study
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In brief
In brief
Retrospective study of 146 Hirschsprung disease patients found 8% preoperative and 21% postoperative enterocolitis incidence, with most postoperative cases occurring within the first year after surgery. No specific patient or clinical characteristics predicted postoperative HAEC risk, though affected patients had longer hospital readmissions.
Written by the GCMD Library team from the article.
Introduction
Hirschsprung-associated enterocolitis (HAEC) accounts for substantial morbidity and mortality in patients with Hirschsprung disease (HD). The aim of this study was to identify incidence of pre- and postoperative HAEC in our consecutive cohort and to identify patient and clinical characteristics that are associated with developing postoperative HAEC and HAEC-free interval.
Material and methods
A retrospective cohort study was performed with all 146 HD patients treated between 2000 and 2017. Data were retrieved from the medical records. HAEC was defined as presence of clinical signs of bowel inflammation, that required treatment with intravenous antibiotics and admittance to the hospital during at least two days. To identify risk factor for HAEC, patients with and without a history of postoperative HAEC were compared. Kaplan-Meier and Cox-regression were used to assess HAEC free intervals before and after surgery.
Results
Out of 146 patients, 12 patients had pre-operative HAEC (8%) and 31 patients had postoperative HAEC (21%). Median preoperative HAEC free interval was 112 days (IQR 182 days). Length of hospital stay due to readmissions was longer for patients with a history of postoperative HAEC compared to patients without a history of postoperative HAEC (9.5 vs 16 days, U=1872.5, p=.047). Median postoperative HAEC free interval was 226 days. Of the patients who had postoperative HAEC, 66% had their first episode within the first year after surgery and that the incidence of HAEC declined over follow-up.
Conclusions
HAEC incidence was relatively low in our population. No patient or clinical characteristics were associated with the risk of postoperative HAEC.