Risk Factors and Prognostic Effects of Cholangitis after Kasai Procedure in Biliary Atresia Patients: A Retrospective Clinical Study
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In brief
In brief
This retrospective study of 180 biliary atresia patients identifies elevated pre-operative gamma-glutamyl transferase as a risk factor for post-Kasai cholangitis, which occurred in 66% of cases. Older age at surgery and higher liver fibrosis scores predict recurrent cholangitis, informing risk stratification and surveillance strategies in this population.
Written by the GCMD Library team from the article.
Purpose
Cholangitis after Kasai procedure has been previously shown to be related to poor prognosis in Biliary Atresia (BA). To investigate the risk factors and clinical outcomes of cholangitis, we did a retrospective study in post-Kasai BA patients.
Methods
Two-year follow-up data of 180 type-III BA patients after Kasai procedure in 2016 in our hospital were analyzed, including 119 cholangitis patients (66.11%). Among the cholangitis group, patients were further divided into early vs late cholangitis and single vs recurrent cholangitis groups. Liver pathology, liver function, cholangitis occurrence and frequency, jaundice clearance, and survival rates were examined.
Results
Higher gamma-glutamyl transferase level before Kasai is a risk factor for cholangitis (p = 0.0393). Older age and higher liver fibrosis score at Kasai are risk factors for recurrent cholangitis (p