REVISITING INHALED NITRIC OXIDE UTILIZATION IN CONGENITAL DIAPHRAGMATIC HERNIA: A NATIONAL COHORT STUDY OF MAJOR CHILDREN’S HOSPITALS IN THE UNITED STATES

In brief

This national cohort study examines current patterns of inhaled nitric oxide (iNO) use in infants with congenital diaphragmatic hernia across major U.S. children's hospitals, despite longstanding evidence questioning its efficacy for CDH-associated pulmonary hypertension. The research provides insights into contemporary practice variations in managing this complex neonatal condition.

• Inhaled nitric oxide (iNO) lacks proven efficacy for pulmonary hypertension in CDH despite over a decade of evidence.
• Contemporary practice patterns show continued iNO use in CDH infants across major U.S. children's hospitals.
• Hospital-level variation exists in iNO utilization for CDH, suggesting need for standardized evidence-based protocols.
• Clinicians should critically evaluate iNO use in CDH cases given limited supporting data for this specific population.

Written by the GCMD Library team from the article.