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Article1 min read·Published Jun 2019Older

Reply to Letter to the Editor

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Article · Jun 2019 · 1 min read

In brief

In brief

Response to correspondence regarding the association between congenital diaphragmatic hernia (CDH) and undescended testis (UDT). Authors acknowledge the potential role of WT1 gene in linking these conditions and suggest further investigation into genetic mechanisms underlying this association.

Written by the GCMD Library team from the article.

We thank Professor Hutson for his interest in our study and for investigating other possible solutions for this association. Genetics could play an important role in this, although we could not verify this with our patient data because there were no significant differences in genetic anomalies in the patients with or without an UDT. We did not find an association with the syndromal CDH patients, because most CDH with an UDT had an isolated CDH. WT1 is known to be associated with an UDT/ urogenital anomalies and could have a factor in this association with a CDH, which is interesting to explore further.

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