Regenerative medicine: current research and perspective in pediatric surgery
link.springer.com shows its articles on its own site.
Read the article on link.springer.com ↗Article · Apr 2023 · 1 min read
In brief
In brief
This review examines advances in regenerative medicine and tissue engineering for pediatric surgical applications, focusing on stem cell manipulation, gene therapy, and biomaterial development. Key challenges include achieving proper cell distribution, vascularization, innervation, and immunomodulation to create transplantable bioengineered organs for clinical use.
Written by the GCMD Library team from the article.
Abstract
The field of regenerative medicine, encompassing several disciplines including stem cell biology and tissue engineering, continues to advance with the accumulating research on cell manipulation technologies, gene therapy and new materials. Recent progress in preclinical and clinical studies may transcend the boundaries of regenerative medicine from laboratory research towards clinical reality. However, for the ultimate goal to construct bioengineered transplantable organs, a number of issues still need to be addressed. In particular, engineering of elaborate tissues and organs requires a fine combination of different relevant aspects; not only the repopulation of multiple cell phenotypes in an appropriate distribution but also the adjustment of the host environmental factors such as vascularisation, innervation and immunomodulation. The aim of this review article is to provide an overview of the recent discoveries and development in stem cells and tissue engineering, which are inseparably interconnected. The current status of research on tissue stem cells and bioengineering, and the possibilities for application in specific organs relevant to paediatric surgery have been specifically focused and outlined.