Rectal suction biopsy versus incisional rectal biopsy in the diagnosis of Hirschsprung disease
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Read the article on pubmed.ncbi.nlm.nih.gov ↗Article · Nov 2022 · 1 min read
In brief
In brief
Comparative study of 258 rectal biopsy procedures demonstrates incisional technique significantly outperforms suction biopsy in children over 6 months, with inadequacy rates of 0.9% vs 24.1%. Findings suggest incisional biopsy should be preferred method for Hirschsprung disease diagnosis in older infants and children.
Written by the GCMD Library team from the article.
Background: Hirschsprung disease is one of the most common congenital anomalies that affect colorectal function. Rectal biopsy demonstrating the absence of ganglion cells in the affected bowel is the gold standard for diagnosis. Suction and incisional rectal biopsies are appropriate methods for obtaining diagnostic tissue. The goal of this study is to determine if any differences in adequacy exist between suction and incisional rectal biopsies at our institution.
Methods: We conducted a retrospective review of suction and incisional rectal biopsies for inadequacy per procedure at a tertiary pediatric hospital. Each procedure for rectal biopsy was also evaluated by a number of biopsies per procedure. We used a two-sample test of proportions to compare the inadequacy of suction vs. incisional biopsies.
Results: 133 rectal suction biopsy procedures (227 biopsies) and 125 incisional biopsy procedures (140 biopsies) were analyzed. In patients 6 months of age and older, the percentage of inadequate procedures was substantially higher in the suction biopsy group (24.1% vs 0.9%, p < 0.01).
Conclusions: A substantially higher proportion of inadequacy was found in the suction rectal biopsy group compared to the incisional cohort among the older patient cohort, suggesting incisional biopsies should be strongly considered as the primary rectal biopsy method in patients older than 6 months.
DOI: 10.1007/s00383-022-05246-4